Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Oct 2, 2025

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

Resveratrol: Potential Application in Sepsis.

Jiajia Li¹, Xiaoting Zeng¹, Fuxun Yang¹

¹Department of ICU, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

Frontiers in Pharmacology

|February 28, 2022

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Correction: Immune cell senescence and chronic bone diseases: osteoimmune mechanisms and therapeutic perspectives.

Frontiers in immunology·2026

Same author

Targeting the cGAS-STING pathway alleviates neuroinflammation and cognitive impairment induced by chronic infection of Toxoplasma gondii.

Journal of neuroinflammation·2026

Same author

Immune cell senescence and chronic bone diseases: osteoimmune mechanisms and therapeutic perspectives.

Frontiers in immunology·2026

Same author

Trem2 exacerbates ischemic brain injury through Gpnmb in a photothrombotic stroke model.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same author

Diagnosis of right coronary artery-right atrial fistula with an atrial septal defect by echocardiography: a case description and literature analysis.

Quantitative imaging in medicine and surgery·2026

Same author

Clostridium butyricum ameliorates Toxoplasma gondii-induced neuropsychiatric disorders by attenuating glial-mediated synaptic pruning via the gut-brain axis.

Journal of neuroinflammation·2026

Resveratrol, a natural compound, shows promise in treating sepsis by protecting organs and reducing mortality in animal models. Further clinical research is needed to explore its therapeutic potential for this life-threatening condition.

Area of Science:

Biochemistry and Pharmacology
Critical Care Medicine
Infectious Diseases

Background:

Sepsis is a life-threatening organ dysfunction syndrome resulting from dysregulated host responses to infection.
Resveratrol, a natural polyphenol, exhibits anti-inflammatory, antioxidant, and organ-protective properties.
Previous studies suggest resveratrol may improve outcomes in animal models of sepsis.

Purpose of the Study:

To review and prospect the potential of resveratrol for sepsis treatment.
To analyze recent research (2021) on resveratrol and sepsis.
To provide a basis for future clinical investigations into resveratrol as a sepsis therapy.

Main Methods:

Literature search of Medline (PubMed) and Embase databases.

Keywords:

SIRT-1 animal model antioxidation organ protection resveratrol sepsis

More Related Videos

Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies

Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies

Published on: April 11, 2012

Cecal Ligation Puncture Procedure

Cecal Ligation Puncture Procedure

Published on: May 7, 2011

Related Experiment Videos

Last Updated: Oct 2, 2025

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies

Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies

Published on: April 11, 2012

Cecal Ligation Puncture Procedure

Cecal Ligation Puncture Procedure

Published on: May 7, 2011

Inclusion of studies published in 2021.

Keywords used: "resveratrol" and "sepsis".

Main Results:

Resveratrol demonstrates organ protective effects in sepsis animal models.
Resveratrol has been shown to improve survival rates and reduce mortality in sepsis.
The compound's anti-inflammatory and other inhibitory properties are relevant to sepsis.

Conclusions:

Resveratrol holds potential as a therapeutic agent for sepsis.
Further clinical research is warranted to validate these findings in human patients.
Resveratrol's multifaceted protective effects make it a candidate for sepsis management.