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Related Experiment Video

Updated: Oct 2, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Diagnostic Delay and Its Predictors in Cluster Headache.

Byung-Su Kim1, Pil-Wook Chung2, Byung-Kun Kim3

  • 1Department of Neurology, Daejin Medical Center, Bundang Jesaeng General Hospital, Seongnam, South Korea.

Frontiers in Neurology
|February 28, 2022
PubMed
Summary
This summary is machine-generated.

Younger patients with cluster headache (CH) face longer diagnostic delays, impacting their disease burden. Improved diagnostic criteria and education have reduced delays over time.

Keywords:
Koreacluster headachedelayed diagnosisheadacheprimary headache disorder

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Area of Science:

  • Neurology
  • Headache Medicine

Background:

  • Cluster headache (CH) is a rare, debilitating primary headache disorder.
  • Delayed diagnosis of CH exacerbates patient suffering and disease burden.

Purpose of the Study:

  • To investigate the diagnostic delay in cluster headache patients.
  • To identify predictors of diagnostic delay and its clinical impact.

Main Methods:

  • Analysis of data from a 4-year prospective multicenter CH registry.
  • Diagnosis of CH based on International Classification of Headache Disorders (ICHD)-3 criteria.
  • Assessment of diagnostic delay as time from onset to diagnosis, categorized into tertiles.

Main Results:

  • Mean diagnostic delay was 5.7 years; younger patients (<20 years) had higher delays.
  • Episodic, chronic, and probable CH were associated with longer diagnostic delays.
  • Increased diagnostic delay correlated with higher prevalence of suicidal ideation and HIT-6 scores.

Conclusions:

  • Younger age of onset is a significant predictor of delayed CH diagnosis.
  • Improved diagnostic criteria (ICHD) and patient education have reduced diagnostic delays over time.
  • Reducing diagnostic delay is crucial for mitigating the disease burden of cluster headache.