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Related Experiment Video

Updated: Oct 2, 2025

Investigating Intestinal Inflammation in DSS-induced Model of IBD

Investigating Intestinal Inflammation in DSS-induced Model of IBD

Published on: February 1, 2012

Case Report: A Peculiar Case of Inflammatory Colitis After SARS-CoV-2 Infection.

Mariangela Rutigliani¹, Matteo Bozzo², Andrea Barberis³

¹Department of Laboratory and Service - Histological and Anatomical Pathology Unit, Ente Ospedaliero (E.O.) Galliera Hospital, Genova, Italy.

Frontiers in Immunology

|February 28, 2022

Summary

Severe COVID-19 can trigger inflammatory colitis by altering immune checkpoints. This study links SARS-CoV-2 infection to a breakdown in PD-1/PD-L1 interaction, potentially causing fatal autoinflammatory responses.

Keywords:

COVID-19 PD-1/PD-L1 axis SARS-CoV-2 cytotoxic immune cells necrotizing ulcerative colitis

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Last Updated: Oct 2, 2025

Investigating Intestinal Inflammation in DSS-induced Model of IBD

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Published on: February 1, 2012

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Chronic Salmonella Infection Induced Intestinal Fibrosis

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Area of Science:

Immunology
Gastroenterology
Virology

Background:

SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) infection is known to cause immunological alterations.
Investigating immune checkpoints like PD-1 (Programmed cell death protein 1) and PD-L1 (Programmed death-ligand 1) may elucidate mechanisms of self-tolerance breakdown.

Observation:

SARS-CoV-2 viral RNA and nucleocapsid protein were detected in colon tissue of a patient with fatal inflammatory colitis.
PD-1 and PD-L1 expression was observed in inflamed, non-ulcerated mucosal areas but was undetectable in ulcerated regions.

Findings:

Compared to healthy tissue, inflamed colon tissue showed altered expression of PD-1 and PD-L1.
The PD-1/PD-L1 axis interaction was disrupted in the context of SARS-CoV-2-induced colitis.

Implications:

The findings suggest a potential link between SARS-CoV-2 infection and aberrant autoinflammatory responses.
Breakdown of the PD-1/PD-L1 interaction may contribute to severe outcomes, including early mortality, in SARS-CoV-2 patients.