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Related Concept Videos

Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

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Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
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Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

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Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
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Mechanism of Cardiac Arrhythmias01:28

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Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
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Cardiomyopathy I: Introduction and Classification01:25

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Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
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Development of the Heart01:27

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The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
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Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos
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CCBE1 in Cardiac Development and Disease.

Fernando Bonet1,2,3, José M Inácio1, Oriol Bover1

  • 1Stem Cells and Development Laboratory, CEDOC, Chronic Diseases Research Centre, NOVA Medical School, Universidade Nova de Lisboa, Lisboa, Portugal.

Frontiers in Genetics
|February 28, 2022
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Summary

Collagen- and calcium-binding EGF-like domains 1 (CCBE1) is crucial for lymphatic and heart development. This review explores CCBE1

Keywords:
CCBE1Hennekam syndromecardiogenesiscoronary vesselscvdlymphangiogenesisproliferation

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Area of Science:

  • Developmental Biology
  • Cardiovascular Research
  • Regenerative Medicine

Background:

  • Collagen- and calcium-binding EGF-like domains 1 (CCBE1) is essential for lymphangiogenesis and VEGF-C signaling.
  • CCBE1 mutations cause Hennekam syndrome, a lymphatic malformation disorder with cardiac defects.
  • Emerging evidence highlights CCBE1's critical role in heart development.

Purpose of the Study:

  • To review the multifaceted roles of CCBE1 in cardiac development and function.
  • To discuss the implications of CCBE1 in human cardiac diseases.
  • To explore CCBE1's therapeutic potential in regenerative medicine for heart conditions.

Main Methods:

  • Review of existing literature on CCBE1's function in cardiac development.
  • Analysis of CCBE1 expression patterns in cardiac progenitor cells and embryonic hearts.
  • Examination of CCBE1's role in coronary vessel formation and stem cell differentiation.

Main Results:

  • CCBE1 is expressed in key cardiac progenitor populations and the developing epicardium.
  • CCBE1 is indispensable for proper coronary vessel and coronary artery stem formation in mice.
  • CCBE1 is vital for the differentiation of embryonic stem cell-derived cardiac lineages.

Conclusions:

  • CCBE1 plays a conserved and essential role in both lymphatic and cardiac development.
  • Dysregulation of CCBE1 is linked to congenital heart defects and cardiovascular diseases.
  • CCBE1 represents a promising target for novel therapeutic strategies in cardiovascular regenerative medicine.