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Bioreactor design and validation for manufacturing strategies in tissue engineering
Diana Lim1, Eric S Renteria1, Drake S Sime1
1Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Bio-Design and Manufacturing
|February 28, 2022
Summary
Bioreactors are essential for tissue engineering, requiring precise control of the in vivo environment for product maturation. This review covers bioreactor design, automation, and real-time monitoring for quality assurance in regenerative medicine.
Area of Science:
- Regenerative medicine and tissue engineering
Background:
- Tissue-engineered products require specific conditions for maturation before implantation.
- Bioreactors must replicate the in vivo mechanical, electrochemical, and biochemical environment.
Purpose of the Study:
- To review bioreactor engineering considerations for tissue-engineered products.
- To discuss strategies for automation, in-line monitoring, and quality assurance.
Main Methods:
- Overview of bioreactor engineering principles.
- Discussion of automation and monitoring strategies.
Main Results:
- Bioreactor design is critical for maximizing the biological function of engineered tissues.
- Real-time monitoring is essential for quality management during manufacturing.
Conclusions:
- Optimized bioreactor conditions are necessary for successful tissue engineering.
- Automation and in-line monitoring enhance quality assurance in regenerative medicine manufacturing.
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