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Related Concept Videos

Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

754
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
754
Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

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Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
155

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Related Experiment Video

Updated: Oct 2, 2025

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
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Negative Appendicectomy Rate: Incidence and Predictors.

Khaled Noureldin1,2, Ali Asgar Hatim Ali3, Mohamed Issa4

  • 1General Surgery, Cairo University Hospital, Cairo, EGY.

Cureus
|February 28, 2022
PubMed
Summary
This summary is machine-generated.

Negative appendicectomy (NA) remains a challenge, with higher rates observed in females. Female gender, prolonged symptoms, and lower white blood cell counts are key predictors of NA after appendicectomy.

Keywords:
emergency appendicectomyincidence of negative appendicitisnegative appendicectomyoutcome of appendicectomypain right iliac fossapredictors of negative appendicectomy

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Area of Science:

  • Emergency Medicine
  • Surgical Pathology
  • Diagnostic Accuracy

Background:

  • Acute appendicitis is a common surgical emergency.
  • Appendicectomy, the standard treatment, carries risks including negative appendicectomy (NA).
  • The incidence of NA ranges from 15% to 39%.

Purpose of the Study:

  • To determine the rate of negative appendicectomy (NA) in a patient cohort.
  • To identify predictors associated with NA.
  • To analyze laboratory parameters in diagnosing acute appendicitis.

Main Methods:

  • Retrospective study analyzing data from emergency appendicectomies over one year.
  • NA defined by absence of inflammatory process/cells in the appendix.
  • Laboratory parameters (WBC, CRP, bilirubin) and patient demographics collected.

Main Results:

  • 372 patients included; 93.5% underwent laparoscopic appendicectomy.
  • Negative appendicectomy rate (NAR) was 10.2% (standard criteria) and 25.8% (strict criteria).
  • NAR significantly higher in females (39.4%) vs. males (11.1%); younger patients, lower WBC, CRP, and bilirubin levels were associated with NA.

Conclusions:

  • Negative appendicectomy (NA) is a significant issue in managing right lower abdominal pain.
  • Female gender, symptom duration >3 days, and lower total white blood cell (WBC) count independently predict NA.
  • Findings suggest a need for improved diagnostic strategies to reduce NA rates.