Related Experiment Video
Updated: Oct 2, 2025

07:35
Gene Transfer for Ischemic Heart Failure in a Preclinical Model
Published on: May 15, 2011
13.0K
Acute Myocardial Infarction After Coronavirus Vaccine: A Rare Adverse Effect.
Sameen Iqbal1, Ghufran Adnan1, Awais Farhad1
1Cardiology, Aga Khan University, Karachi, PAK.
Cureus
|February 28, 2022
Summary
A man experienced acute coronary syndrome after his first Moderna COVID-19 vaccine dose. While rare, this highlights the need for vigilance and monitoring of vaccine side effects.
Area of Science:
- Cardiology
- Immunology
- Vaccinology
Background:
- The global rollout of coronavirus disease 2019 (COVID-19) vaccines aims to curb the pandemic.
- Understanding potential adverse events following immunization is crucial for public health.
- Pre-existing conditions may influence vaccine response and risk of adverse events.
Observation:
- A 61-year-old male with ischemic heart disease developed acute coronary syndrome (ACS).
- Symptoms of left arm and jaw pain began 90 minutes post-Moderna COVID-19 vaccination.
- The patient was diagnosed with non-ST-elevation myocardial infarction.
Findings:
- Percutaneous coronary intervention was performed successfully.
- The patient was discharged after a two-day hospital stay and was clinically stable.
- The temporal association suggests a possible link between the COVID-19 vaccine and the ACS event in this high-risk individual.
Implications:
- Healthcare providers must be aware of potential rare vaccine side effects.
- Further investigation and risk assessment may be warranted for high-risk patients before vaccination.
- Continued monitoring of vaccine safety data is essential to prevent future adverse events and maintain public confidence in vaccination programs.
Related Concept Videos
Myocarditis III: Medical Management
27
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
27
Myocarditis I: Introduction
52
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
52
Coronary Artery Disease III: Clinical Manifestations
54
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
54
Acute Coronary Syndrome I: Introduction
103
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
103
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
67
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
67
Myocarditis II: Clinical Features and Diagnostic Tests
37
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
37

