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Severity of adverse reactions is associated with T-cell response in mRNA-1273 vaccinated health care workers

Hanna Klingel1, Maike Lauen1, Alexander Krüttgen1

  • 1Laboratory Diagnostic Center, University Hospital RWTH Aachen, Aachen, Germany.

Clinical and Experimental Vaccine Research
|February 28, 2022
PubMed

Knowledge about mRNA-1273 elicited T-cell response is limited. We investigated adverse reactions and interferon gamma release by specific T-cells among mRNA-1273 vaccinated health care workers. Seven to 13 weeks after complete vaccination low levels of specific T-cells were detected not correlating with antibody response. Severity of symptoms after first and number of symptoms after second immunization were associated with T-cell response. Assessment of T-cell response in addition to antibody response is crucial because even few specific T-cells could add to protection against infection. Investigation of mRNA-1273 induced inflammatory processes might help improve reactogenicity and immunogenicity.

Keywords:
Adverse reactionsAntibody responseSARS-CoV-2T-cell responseVaccine mRNA-1273

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