Related Experiment Video

Updated: Oct 2, 2025

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.4K

Correlation Between Matrix Metalloproteinases With Coronary Artery Lesion Caused by Kawasaki Disease

Fang Tian1,2, Linxi Ma3, Renbing Zhao2

  • 1Heart Center of Women and Children Hospital of Qingdao University, Qingdao, China.

Frontiers in Pediatrics
|February 28, 2022
PubMed

Insights

Matrix metalloproteinases (MMPs) are elevated in children with Kawasaki disease (KD) and coronary artery lesions (CAL). Intravenous immunoglobulin therapy reduced MMP levels, highlighting MMPs as potential biomarkers for CAL in KD.

Area of Science:

  • Cardiovascular Research
  • Pediatric Immunology
  • Biochemistry

Background:

  • Kawasaki disease (KD) is a leading cause of acquired pediatric heart disease.
  • Coronary artery lesions (CAL) are a serious complication of KD.
  • The role of matrix metalloproteinases (MMPs) in CAL development is not fully understood.

Purpose of the Study:

  • To investigate the association between MMP-2 and MMP-9 levels and CAL in children with KD.
  • To evaluate the effect of intravenous immunoglobulin (IVIG) therapy on MMP levels in KD patients.
  • To explore correlations between MMP levels and clinical parameters in KD.

Main Methods:

  • Serum samples collected from healthy, febrile, and KD children (with or without CAL).
  • Enzyme-linked immunosorbent assay (ELISA) used to quantify MMP-2 and MMP-9 levels.
  • Comparison of MMP levels before and after IVIG treatment in KD patients.

Main Results:

  • MMP-2 and MMP-9 levels were significantly higher in KD patients with CAL compared to those without.
  • IVIG treatment effectively downregulated MMP levels, particularly in patients with CAL.
  • MMP levels correlated significantly with clinical indicators like fever duration and white blood cell count.

Conclusions:

  • Elevated MMP-2 and MMP-9 levels are strongly associated with coronary artery lesions in Kawasaki disease.
  • MMPs show potential as biomarkers for identifying KD patients at risk for CAL.
  • IVIG therapy demonstrates efficacy in modulating MMP levels in KD patients.

Keywords:
IVIG therapyKD patientsKawasaki diseasecoronary artery lesionsmatrix metalloproteinases

More Related Videos

A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue13:45

A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue

Published on: November 11, 2022

2.2K
Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

19.7K

Related Concept Videos

Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
70
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
67
Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
2.6K
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
52
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
36
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
145