Pediatric Sepsis Research: Where Are We and Where Are We Going?

Letícia Massaud-Ribeiro1,2, Pedro Henrique Nunes Costa Silami2,3, Fernanda Lima-Setta2,4

  • 1Pediatric Intensive Care Unit, Department of Pediatrics, Instituto de Puericultura e Pediatria Martagão Gesteira, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Frontiers in Pediatrics
|February 28, 2022
PubMed

Insights

Pediatric sepsis remains a critical challenge in intensive care. This review highlights the most impactful research on pediatric sepsis published in the 21st century, offering insights into key findings and future directions.

Area of Science:

  • Pediatric critical care medicine
  • Infectious diseases
  • Medical research impact analysis

Background:

  • Sepsis is a leading cause of Pediatric Intensive Care Unit admissions.
  • Managing pediatric sepsis presents significant challenges for healthcare professionals and researchers.
  • Understanding the evolution of research is crucial for advancing treatment strategies.

Purpose of the Study:

  • To review and assess the most influential research on pediatric sepsis.
  • To identify key findings and future perspectives from highly cited studies.
  • To analyze the trends in pediatric sepsis research over time.

Main Methods:

  • Systematic literature search of the Scopus database.
  • Selection of the 100 most cited articles on pediatric sepsis.
  • Categorization of selected articles into two periods: 2000-present and 2016-present.
  • Analysis of findings and perspectives from the most impactful studies.

Main Results:

  • Identified the 100 most cited articles from 2,698 retrieved studies.
  • Highlighted significant research contributions published in the 21st century.
  • Summarized key findings and future research directions from influential studies.

Conclusions:

  • The 21st century has seen significant advancements and highly impactful research in pediatric sepsis.
  • Continued focus on high-impact research is essential for improving outcomes in pediatric sepsis.
  • Further investigation into emerging trends and perspectives is warranted.