Related Experiment Video
Updated: Oct 2, 2025

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis
Published on: January 27, 2019
Pediatric Sepsis Research: Where Are We and Where Are We Going?
Letícia Massaud-Ribeiro1,2, Pedro Henrique Nunes Costa Silami2,3, Fernanda Lima-Setta2,4
1Pediatric Intensive Care Unit, Department of Pediatrics, Instituto de Puericultura e Pediatria Martagão Gesteira, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Insights
Pediatric sepsis remains a critical challenge in intensive care. This review highlights the most impactful research on pediatric sepsis published in the 21st century, offering insights into key findings and future directions.
Area of Science:
- Pediatric critical care medicine
- Infectious diseases
- Medical research impact analysis
Background:
- Sepsis is a leading cause of Pediatric Intensive Care Unit admissions.
- Managing pediatric sepsis presents significant challenges for healthcare professionals and researchers.
- Understanding the evolution of research is crucial for advancing treatment strategies.
Purpose of the Study:
- To review and assess the most influential research on pediatric sepsis.
- To identify key findings and future perspectives from highly cited studies.
- To analyze the trends in pediatric sepsis research over time.
Main Methods:
- Systematic literature search of the Scopus database.
- Selection of the 100 most cited articles on pediatric sepsis.
- Categorization of selected articles into two periods: 2000-present and 2016-present.
- Analysis of findings and perspectives from the most impactful studies.
Main Results:
- Identified the 100 most cited articles from 2,698 retrieved studies.
- Highlighted significant research contributions published in the 21st century.
- Summarized key findings and future research directions from influential studies.
Conclusions:
- The 21st century has seen significant advancements and highly impactful research in pediatric sepsis.
- Continued focus on high-impact research is essential for improving outcomes in pediatric sepsis.
- Further investigation into emerging trends and perspectives is warranted.
Abstract:
Sepsis continues to be one of the leading causes of admission to the Pediatric Intensive Care Unit, representing a great challenge for researchers and healthcare staff. This mini review aims to assess research on pediatric sepsis over the years. Of the 2,698 articles retrieved from the Scopus database, the 100 most cited were selected (50 published since 2000 and 50 published since 2016). The most cited studies, published in the 21st century, are highlighted, with their main findings and perspectives.
Related Concept Videos
Acute Pyelonephritis II: Diagnostic Studies and Management
Acute Kidney Injury IV: Diagnostic Studies and Prevention

