Related Experiment Video

Updated: Oct 2, 2025

Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase
10:33

Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase

Published on: October 15, 2018

8.3K

Clinical Significance of TET2 in Female Cancers

Fang Wan1, Fangfang Chen1, Yangfan Fan1

  • 1Department of Surgery, The Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Frontiers in Bioengineering and Biotechnology
|February 28, 2022
PubMed

Insights

The ten-eleven translocation methylcytosine dioxygenase (TET2) gene shows decreased expression in most female cancers. High TET2 expression correlates with better prognosis and influences immune cell infiltration in various gynecological and breast cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Genomics

Background:

  • Female cancers, including breast and reproductive system tumors, significantly impact women's health.
  • Emerging research suggests a link between ten-eleven translocation methylcytosine dioxygenase (TET2) and female cancers, but comprehensive analysis is lacking.

Purpose of the Study:

  • To investigate the clinical significance and oncogenic roles of TET2 in major female cancers.
  • To analyze TET2 expression, prognostic value, and its relationship with immune infiltration and co-expression networks in female cancers.

Main Methods:

  • Utilized The Cancer Genome Atlas (TCGA) database for comprehensive analysis of TET2.
  • Performed statistical analysis on gene expression, patient prognosis, immune cell infiltration (CD8+ T-cells, fibroblasts), and gene co-expression.
  • Conducted immunohistochemical and immunofluorescence staining on breast cancer tissues for validation.

Main Results:

  • TET2 expression is reduced in most female cancers, with higher expression linked to favorable prognoses.
  • TET2 showed correlations with tumor-associated fibroblast infiltration in breast, cervical, and ovarian cancers.
  • Co-expression analysis revealed TET2's association with immune checkpoint molecules and involvement in tumorigenesis-related pathways.

Conclusions:

  • TET2 exhibits potential as a prognostic biomarker in female cancers.
  • The study provides evidence for TET2's oncogenic functions and its interplay with the tumor microenvironment.
  • Findings support the clinical value of TET2 in understanding and potentially treating female cancers.
Keywords:
GEOTCGATET2female cancersimmune infiltration

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