Related Experiment Video
Updated: Oct 2, 2025
10:17
A Mass Spectrometry-Based Approach to Identify Phosphoprotein Phosphatases and their Interactors
Published on: April 29, 2022
2.5K
Dual-Specificity Phosphatases and Kidney Diseases
Haiyang Li1, Jiachuan Xiong1, Yu Du1
1Department of Nephrology, The Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Chongqing Clinical Research Center of Kidney and Urology Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Kidney Diseases (Basel, Switzerland)
|February 28, 2022
Summary
Dual-specificity phosphatases (DUSPs) are crucial in kidney diseases. Decreased DUSP levels worsen kidney conditions, while increasing DUSP expression can reverse disease progression, highlighting their therapeutic potential.
Area of Science:
- Biochemistry
- Molecular Biology
- Nephrology
Background:
- Dual-specificity phosphatases (DUSPs) dephosphorylate serine/threonine and tyrosine residues.
- DUSPs regulate mitogen-activated protein kinases (MAPKs) and other substrates.
- Dysregulated DUSPs are linked to cancer, neurological disorders, and kidney diseases.
Purpose of the Study:
- To review DUSP characteristics and their role in kidney diseases.
- To explore DUSP involvement in diabetic nephropathy, hypertensive nephropathy, CKD, AKI, and lupus nephritis.
Main Methods:
- Literature review of DUSP research in kidney disease models.
- Analysis of studies using transgenic and gene knockout models.
Main Results:
- DUSPs are implicated in the pathogenesis of various kidney diseases.
- Reduced DUSP expression is observed in kidney disease models.
- Enhanced DUSP expression ameliorates kidney disease phenotypes in experimental models.
Conclusions:
- DUSPs play essential physiological and pathological roles in kidney diseases.
- Understanding DUSP mechanisms is key for clinical translation in nephrology.
- Targeting DUSPs offers potential therapeutic strategies for kidney disorders.
Related Concept Videos
02:54Protein Kinases and Phosphatases
13.6K
Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
13.6K
01:02Phosphorylation
51.8K
The addition or removal of phosphate groups from proteins is the most common chemical modification that regulates cellular processes. These modifications can affect the structure, activity, stability, and localization of proteins within cells as well as their interactions with other proteins.
During phosphorylation, protein kinases transfer the terminal phosphate group of ATP to specific amino acid side chains of substrate proteins. Serine, threonine, and tyrosine are the most commonly...
During phosphorylation, protein kinases transfer the terminal phosphate group of ATP to specific amino acid side chains of substrate proteins. Serine, threonine, and tyrosine are the most commonly...
51.8K
01:27Transducer Mechanism: Enzyme-Linked Receptors
3.0K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Major types that are helpful drug targets include:
3.0K
01:27Roles of Electrolytes: Calcium and Phosphate
570
Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
The calcium concentration in blood plasma is primarily...
The calcium concentration in blood plasma is primarily...
570
01:28Antihypertensive Drugs: Potassium-Sparing Diuretics
842
Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
842
01:10Nephrons
3.7K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
3.7K