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Related Concept Videos

Adhesion01:14

Adhesion

41.9K
Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
Capillary action is a result of water’s adhesive tendencies. When a narrow...
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Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

7.7K
Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved...
7.7K
Noncovalent Attractions in Biomolecules02:35

Noncovalent Attractions in Biomolecules

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Noncovalent attractions are associations within and between molecules that influence the shape and structural stability of complexes. These interactions differ from covalent bonding in that they do not involve sharing of electrons.
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...
57.6K
Cohesion01:07

Cohesion

56.3K
Cohesion is the attraction between molecules of the same type, such as water molecules. Water molecules have an overall neutral charge but are polar molecule. An oxygen atom in one water molecule has a partial negative charge that can bind to a hydrogen atom with a partial positive charge in a second water molecule, forming a hydrogen bond. Each water molecule can form up to four hydrogen bonds with other water molecules. Hydrogen bonds are responsible for water's cohesive nature.
On a...
56.3K
Cell Adhesion in Plants01:14

Cell Adhesion in Plants

2.9K
Plants have rigid cell walls that are made up of cell wall polysaccharides that mediate cell-cell adhesion. The primary cell walls of plants consist of two independent and interacting polysaccharide networks: a pectin matrix that embeds the second network comprising cellulose and hemicelluloses.
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose,...
2.9K
Anchoring Junctions01:03

Anchoring Junctions

4.0K
Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
4.0K

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Adhesion Frequency Assay for In Situ Kinetics Analysis of Cross-Junctional Molecular Interactions at the Cell-Cell Interface
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Cohesion mechanisms for bioadhesives.

Yazhong Bu1,2, Abhay Pandit2

  • 1Institute of Medical Engineering, Department of Biophysics, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, China.

Bioactive Materials
|February 28, 2022
PubMed
Summary

Bioadhesives are revolutionizing medical practices through non-invasive wound closure and device immobilization. This review highlights cohesion mechanisms, crucial for bioadhesive strength and application, offering a roadmap for commercialization.

Keywords:
BioadhesiveCohesionHydrogelMedical device fixationSealant

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Adhesion Frequency Assay for In Situ Kinetics Analysis of Cross-Junctional Molecular Interactions at the Cell-Cell Interface
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Area of Science:

  • Biomaterials Science
  • Medical Device Technology
  • Surgical Innovation

Background:

  • Bioadhesives are increasingly important in clinical settings for non-invasive wound closure, leak sealing, and device immobilization.
  • The performance of bioadhesives is critically dependent on both adhesion and cohesion mechanisms.
  • While adhesion mechanisms are well-documented, cohesion mechanisms in bioadhesives remain under-explored.

Purpose of the Study:

  • To comprehensively review and summarize the primary cohesion mechanisms employed in bioadhesives.
  • To elucidate the relationship between cohesion strategies and adhesion strategies in bioadhesive design.
  • To provide a foundational understanding to accelerate the commercialization of advanced bioadhesives.

Main Methods:

  • Literature review of published research on bioadhesive mechanisms.
  • Analysis of reported cohesion strategies and their impact on bioadhesive properties.
  • Synthesis of findings to establish connections between adhesion and cohesion mechanisms.

Main Results:

  • Identified and summarized key cohesion mechanisms utilized in bioadhesives.
  • Demonstrated how cohesion strategies can be integrated with adhesion strategies, including using shared functional groups or combinatorial approaches.
  • Highlighted the influence of cohesion on bulk properties and application methods of bioadhesives.

Conclusions:

  • Understanding and optimizing cohesion mechanisms are vital for enhancing bioadhesive performance and clinical utility.
  • Strategic integration of cohesion and adhesion mechanisms can lead to superior bioadhesive formulations.
  • This review provides a critical roadmap to guide future research and development for bioadhesive commercialization.