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Related Concept Videos

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Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...
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Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...

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Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications
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Functionalized Boron Nanoparticles as Potential Promising Antimalarial Agents.

Yinghuai Zhu1, Parichat Prommana2, Narayan S Hosmane3

  • 1State Key Laboratory of Anti-Infective Drug Development (NO 2015DQ780357), Sunshine Lake Pharma Co., Ltd., Songshan Lake Industrial Park, Dongguan 523871, China.

ACS Omega
|February 28, 2022
PubMed
Summary

Hydroxyl-functionalized boron nanoparticles show potent antimalarial activity against Plasmodium falciparum. These nanoparticles exhibit low toxicity to various human and rat cell lines, indicating potential therapeutic applications.

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Area of Science:

  • Nanotechnology
  • Medicinal Chemistry
  • Parasitology

Background:

  • Boron nanoparticles (BNPs) are emerging materials with diverse applications.
  • Functionalization of nanoparticles can enhance their biological properties.
  • Malaria remains a significant global health challenge requiring novel therapeutic agents.

Purpose of the Study:

  • To synthesize and characterize hydroxyl-functionalized boron nanoparticles (BNPs).
  • To evaluate the in vitro antimalarial activity of these BNPs against Plasmodium falciparum.
  • To assess the in vitro toxicity of BNPs against various human and rat cell lines.

Main Methods:

  • In situ synthesis of hydroxyl-functionalized BNPs via a cascade process.
  • Characterization using NMR, FT-IR, ICP-OES, TEM, DLS, and XPS.
  • In vitro antimalarial assay against Plasmodium falciparum (3D7 strain).
  • In vitro cytotoxicity assessment using U87MG, A375, KB, rat cortical neurons, and FLS cell lines.

Main Results:

  • Successful synthesis of hydroxyl-functionalized BNPs.
  • BNPs demonstrated significant antimalarial activity with an IC50 value of 0.0021 μM.
  • Low toxicity observed across multiple tested cell lines, including cancer and neuronal cells.

Conclusions:

  • Hydroxyl-functionalized BNPs are effective against Plasmodium falciparum in vitro.
  • These BNPs exhibit a favorable safety profile with low cytotoxicity.
  • Functionalized BNPs represent a promising platform for developing new antimalarial therapies.