Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Parkinson's Disease: Treatment

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...

Parkinson's Disease: Overview

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...

Physiology of Enteric Nervous System and Gut Health

Physiology of Enteric Nervous System and Gut Health

The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...

Neural Regulation

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.

Enteric Nervous System: Regulation of GI Motor Activity

Enteric Nervous System: Regulation of GI Motor Activity

The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...

Gastrointestinal Motility Disorders

Gastrointestinal Motility Disorders

Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Sex- and Sport-Specific Differences in Jump Strategies: Key Qualities for Jump Performance.

Sports (Basel, Switzerland)·2025

Same author

Longitudinal associations between physical performance and cognition in individuals with Parkinson's disease.

Clinical parkinsonism & related disorders·2025

Same author

Consensus on the Use of Therapeutic Interventions in Pain Management, Recovery, and Athletic Performance: A Delphi Study.

International journal of sports physical therapy·2025

Same author

The role of transcutaneous electrical nerve stimulation for menstrual pain relief: A randomized control trial.

Women's health (London, England)·2024

Same author

Initial development of skill with a reversed bicycle and a case series of experienced riders.

Scientific reports·2024

Same author

Reliability of a method to assess corticomotor excitability of lower limb muscles using a normalized EMG motor thresholding procedure.

Scientific reports·2024

Search research articles

Related Experiment Video

Updated: Oct 2, 2025

Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease

Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease

Published on: September 22, 2023

Rethinking Parkinson Disease: Exploring Gut-Brain Interactions and the Potential Role of Exercise.

Kaylie Zapanta¹, E Todd Schroeder¹, Beth E Fisher^1,2

¹Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California, USA.

Physical Therapy

|February 28, 2022

Summary

Parkinson disease (PD) may be influenced by gut bacteria imbalances. Exercise may improve PD symptoms by restoring gut microbiota, offering a new therapeutic approach for physical therapists.

Keywords:

Cognitive Function Exercise Physiology Exercise: Aerobic Performance Exercise: Motor Performance Parkinson Disease Psychomotor Disorders

More Related Videos

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

Related Experiment Videos

Last Updated: Oct 2, 2025

Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease

Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease

Published on: September 22, 2023

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

Area of Science:

Neuroscience
Microbiology
Exercise Physiology

Background:

Parkinson disease (PD) is increasingly linked to the gut-brain axis and gut microbiota dysbiosis.
Dysbiosis is associated with both motor and cognitive symptoms in PD and other neurodegenerative conditions.
Exercise is known to benefit motor and cognitive functions in PD and restore gut microbiota in non-PD populations.

Purpose of the Study:

To explore the potential role of gut microbiota restoration in mediating exercise benefits for Parkinson disease.
To review the gut-brain axis, exercise's impact on gut microbiota, and its effects on PD symptoms.

Main Methods:

Literature review of the gut-brain axis in PD.
Examination of exercise-induced gut microbiota changes in non-PD populations.
Synthesis of evidence on exercise benefits for motor and cognitive functions in PD.

Main Results:

Gut microbiota dysbiosis is a significant factor in PD pathogenesis and progression.
Exercise has demonstrated efficacy in improving motor and cognitive functions in individuals with PD.
Evidence suggests exercise can positively modulate gut microbiota composition.

Conclusions:

Exercise benefits in PD may be partly attributed to the restoration of gut microbiota.
Targeting gut microbiota through exercise presents a novel therapeutic strategy for PD management.
Physical therapists can leverage exercise to improve gut health and PD prognosis.