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Predictive role of C-reactive protein in sudden death: a meta-analysis of prospective studies

Ruhua Zhou1, Jingjing Xu2, Jiaochen Luan2

  • 1The College of Nursing, Nanjing Medical University, Nanjing, Jiangsu, China.

The Journal of International Medical Research
|February 28, 2022
PubMed

Insights

C-reactive protein (CRP) predicts cardiovascular disease risk. This meta-analysis confirms CRP is an independent predictor of sudden death (SD), supporting its use in clinical risk assessment.

Area of Science:

  • Cardiovascular Medicine
  • Biomarkers
  • Epidemiology

Background:

  • C-reactive protein (CRP) is a known cardiovascular disease risk factor.
  • The association between CRP and sudden death (SD) remains debated.
  • A comprehensive evaluation is needed to clarify CRP's role in SD prediction.

Purpose of the Study:

  • To conduct a meta-analysis evaluating the association between C-reactive protein (CRP) and sudden death (SD).
  • To determine if CRP is an independent predictor of sudden death.
  • To inform clinical practice regarding CRP measurement for SD risk assessment.

Main Methods:

  • Systematic literature search across multiple databases (PubMed, Web of Science, Embase, etc.).
  • Independent screening and data extraction by two researchers.
  • Meta-analysis of prospective studies using Stata software.

Main Results:

  • Twelve prospective studies with 36,646 patients were included.
  • Higher CRP concentrations were associated with an increased risk of SD (HR, 1.19; 95% CI, 1.09-1.29).
  • Multivariate analysis confirmed CRP as an independent predictor of SD (HR, 1.05; 95% CI, 1.03-1.07).

Conclusions:

  • C-reactive protein (CRP) is confirmed as an independent predictor of sudden death (SD).
  • These findings support the routine measurement of CRP for SD risk stratification in clinical settings.
Abstract

Keywords:
C-reactive proteincardiovascular disease INPLASY registration number: INPLASY2021110074.meta-analysispredictive factorrisk factorsudden death

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