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The effects of methamphetamine on electrocardiographic parameters in male patients

Bahadir Demir1, Filiz Ozsoy2, Ahmet Buyuk3

  • 1Faculty of Medicine, Department of Psychiatry, Gaziantep University, Gaziantep, Turkey.

International Journal of Psychiatry in Clinical Practice
|February 28, 2022
PubMed
Abstract

Insights

Methamphetamine use disorder is linked to significant heart rhythm abnormalities, specifically increased QT dispersion and Tp-e/QTc ratio. This highlights a heightened risk of malignant arrhythmias in individuals with methamphetamine use disorder.

Area of Science:

  • Cardiology
  • Toxicology
  • Psychiatry

Background:

  • Methamphetamine use is associated with various cardiovascular complications.
  • Electrocardiographic (ECG) parameters can indicate cardiac electrical instability.

Purpose of the Study:

  • To compare electrocardiographic parameters between patients with methamphetamine use disorder (MUD) and healthy controls.
  • To identify specific ECG markers associated with MUD.

Main Methods:

  • A cross-sectional case-control study involving 68 patients with MUD and 65 healthy controls.
  • Calculation of heart rate, P wave dispersion, QT dispersion, QTc, and Tp-e/QTc ratios from ECGs.

Main Results:

  • Patients with MUD exhibited significantly higher QT dispersion (13.68 ± 9.12) compared to controls (9.08 ± 7.85).
  • The Tp-e/QTc ratio was significantly elevated in the MUD group compared to healthy controls.
  • No significant differences were found in age, blood pressure, BMI, or lipid profiles between groups.

Conclusions:

  • Methamphetamine use disorder is associated with significant deterioration in QT dispersion and the Tp-e/QTc ratio.
  • These findings suggest an increased risk of malignant arrhythmias in individuals with MUD.
  • Clinical vigilance for arrhythmic events is recommended during the follow-up of MUD patients.
Keywords:
Arrhythmiaelectrocardiographymethamphetaminesubstance-related disorders

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