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Related Experiment Video

Updated: Oct 2, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Damage Trajectories in Systemic Sclerosis Using Group-Based Trajectory Modeling.

Ariane Barbacki¹, Murray Baron¹, Mianbo Wang¹

¹Lady Davis Institute for Medical Research, Montreal, Quebec, Canada.

Arthritis Care & Research

|February 28, 2022

Summary

This summary is machine-generated.

Systemic sclerosis (SSc) patients show distinct damage accrual trajectories. Factors like older age, male sex, and diffuse disease predict higher damage, aiding early intervention for SSc progression.

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Last Updated: Oct 2, 2025

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Area of Science:

Rheumatology and Autoimmune Diseases
Clinical Epidemiology
Disease Progression Modeling

Background:

Systemic sclerosis (SSc) is a severe autoimmune condition causing progressive organ damage.
The Scleroderma Clinical Trials Consortium Damage Index (SCTC-DI) quantifies SSc-related organ damage.
Understanding damage accrual patterns is crucial for effective SSc management.

Purpose of the Study:

To identify distinct trajectories of damage accrual in incident SSc patients.
To determine baseline variables associated with different damage trajectory groups.
To inform early identification of patients requiring aggressive SSc treatment.

Main Methods:

Utilized group-based trajectory modeling on prospective SSc cohort data.
Analyzed SCTC-DI scores over the first 5 annual visits.
Examined univariate and multivariable associations between baseline variables and trajectory membership.

Main Results:

Identified three SCTC-DI trajectories: low (54.6%), medium (36.2%), and high (10.3%) damage accrual.
Higher baseline SCTC-DI scores correlated with faster damage.
Older age, male sex, diffuse SSc, tendon friction rubs, and elevated CRP increased odds of high damage; White ethnicity and anticentromere antibodies decreased these odds.

Conclusions:

Three distinct damage accrual trajectories were identified in incident SSc patients.
Specific baseline characteristics are associated with worse damage trajectories.
These findings can help identify SSc patients needing prompt, aggressive treatment.