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Updated: Oct 2, 2025

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors
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Cardiovascular aspects of the (pro)renin receptor: Function and significance

Chuanming Xu1, Chunju Liu2, Jianhua Xiong3

  • 1Translational Medicine Centre, Jiangxi University of Chinese Medicine, Nanchang, China.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|February 28, 2022
PubMed

Insights

The (Pro)renin receptor (PRR) plays a key role in cardiovascular diseases (CVDs). Targeting PRR may offer new treatments for heart and blood vessel disorders.

Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • Pathophysiology

Background:

  • Cardiovascular diseases (CVDs) are a leading global cause of mortality.
  • The (Pro)renin receptor (PRR) is a transmembrane protein found in heart and blood vessel cells.
  • PRR influences cardiovascular homeostasis via the renin-angiotensin system and intracellular signaling pathways.

Purpose of the Study:

  • To review the pathophysiological roles of cardiac and vascular PRR in CVDs.
  • To discuss the implications of PRR in various cardiovascular conditions.
  • To explore potential therapeutic strategies targeting PRR.

Main Methods:

  • Literature review of current evidence on PRR's role in cardiovascular health and disease.
  • Analysis of studies on PRR activation in different cardiovascular cell types.
  • Examination of animal models and clinical data related to PRR.

Main Results:

  • PRR activation in cardiomyocytes is linked to myocardial ischemia/reperfusion injury, cardiac hypertrophy, cardiomyopathy, and heart failure.
  • PRR activation in vascular cells promotes proliferation, endothelial dysfunction, neovascularization, and vascular disease progression.
  • PRR also influences hypertension and has roles in the brain and kidney.

Conclusions:

  • PRR is a significant contributor to the pathophysiology of various cardiovascular diseases.
  • Targeting PRR in local tissues presents a promising therapeutic avenue for CVDs like heart injury, atherosclerosis, and hypertension.

Keywords:
(pro)renin receptorcardiovascular diseasehearthypertensionrenin-angiotensin systemvascular

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