Related Experiment Video

Updated: Oct 2, 2025

Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence
08:55

Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence

Published on: November 2, 2014

12.4K

TRIM21 deficiency promotes cell proliferation and tumorigenesis via regulating p21 expression in ovarian cancer

Jieyun Sun1,2, Xintian Chen3, Xueying Ji2

  • 1Department of Obstetrics and Gynecology, The First Affiliated Hospital of Soochow University, Suzhou, China.

Bioengineered
|February 28, 2022
PubMed

Insights

Tripartite motif-containing 21 (TRIM21) is decreased in ovarian cancer (OC), hindering cell proliferation and invasion. This suggests TRIM21 could be a potential biomarker and therapeutic target for OC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • The role of Tripartite motif-containing 21 (TRIM21) in cancer is context-dependent, with its function in ovarian cancer (OC) not yet fully understood.
  • Understanding TRIM21's specific role in OC is crucial for developing targeted therapies.

Purpose of the Study:

  • To investigate the biological function of TRIM21 in ovarian cancer progression.
  • To elucidate the underlying mechanisms of TRIM21's action in OC.
  • To assess TRIM21 as a potential diagnostic and therapeutic target for OC.

Main Methods:

  • Analysis of TRIM21 expression in OC tissues and cell lines.
  • Utilized The Cancer Genome Atlas (TCGA) database for survival analysis.
  • Performed in vitro and in vivo functional assays to assess proliferation, migration, and invasion.

Main Results:

  • TRIM21 expression was significantly downregulated in OC tissues and cell lines compared to normal controls.
  • Lower TRIM21 levels correlated with reduced overall and disease-specific survival in OC patients.
  • TRIM21 suppressed OC cell proliferation, migration, and invasion by inhibiting cell cycle progression.

Conclusions:

  • TRIM21 acts as a tumor suppressor in ovarian cancer.
  • Decreased TRIM21 expression is linked to poor prognosis in OC.
  • TRIM21 represents a promising biomarker and therapeutic target for ovarian cancer diagnosis and treatment.
Keywords:
TRIM21migrationovarian cancerproliferation

More Related Videos

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

6.9K
Transplantation Into the Mouse Ovarian Fat Pad09:25

Transplantation Into the Mouse Ovarian Fat Pad

Published on: September 7, 2016

11.5K

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.7K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.9K
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.2K
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
5.2K
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
36.3K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.3K