Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Systematic Error: Methodological and Sampling Errors01:15

Systematic Error: Methodological and Sampling Errors

3.5K
In the case of systematic errors, the sources can be identified, and the errors can be subsequently minimized by addressing these sources. According to the source, systematic errors can be divided into sampling, instrumental, methodological, and personal errors.
Sampling errors originate from improper sampling methods or the wrong sample population. These errors can be minimized by refining the sampling strategy. Defective instruments or faulty calibrations are the sources of instrumental...
3.5K
Uncertainty in Measurement: Accuracy and Precision03:37

Uncertainty in Measurement: Accuracy and Precision

91.4K
Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value. 
91.4K
Variability: Analysis01:11

Variability: Analysis

228
Measures of variability are statistical metrics that reveal the dispersion pattern within a dataset. They are pivotal in biostatistics, providing insights into the heterogeneity within health and biological data. Variability signifies the degree to which data points diverge from one another, helping researchers understand the potential range of values and associated uncertainty within the data.
The range is a simple measure of variability, indicating the difference between the highest and...
228

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Combining biological therapies in patients with inflammatory bowel disease: a Finnish multi-centre study.

Scandinavian journal of gastroenterology·2022
Same author

Prevalence and long-term prognostic implications of prolonged QRS duration in left ventricular hypertrophy: a population-based observational cohort study.

BMJ open·2022
Same author

Impact of obesity on uterine contractile activity during labour: A blinded analysis of a randomised controlled trial cohort.

BJOG : an international journal of obstetrics and gynaecology·2022
Same author

Comparison of zero heat flux and double sensor thermometers during spinal anaesthesia: a prospective observational study.

Journal of clinical monitoring and computing·2022
Same author

Detection and Outcome of Endocervical Atypia in Cytology in Primary HPV Screening Programme.

Diagnostics (Basel, Switzerland)·2021
Same author

Cough and cold medicine prescription rates can be significantly reduced by active intervention.

European journal of pediatrics·2021
Same journal

The Development Path of Gynecological Cytology after Papanicolaou: from Bethesda to Artificial Intelligence and Personalized Medicine.

Acta cytologica·2026
Same journal

Cytological Features of CIC-rearranged Sarcoma. A Report of 5 New Cases and Review of the Literature.

Acta cytologica·2026
Same journal

Pericardial Fluid Metastatic Tumor Distribution and Fluid Volume Analysis, a 10-Year Institutional Experience.

Acta cytologica·2026
Same journal

The cytopathology of infectious disease: A review.

Acta cytologica·2026
Same journal

Investigation of a storage method for peritoneal and pleural effusion cytology specimens for long-term preservation of antigenicity in immunocytochemical staining.

Acta cytologica·2026
Same journal

Diagnostic Utility of endoscopic crush cytology in gastrointestinal malignancies.

Acta cytologica·2026
See all related articles

Related Experiment Video

Updated: Oct 2, 2025

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness
08:52

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Published on: March 18, 2022

3.1K

Endocervical Cytology: Inter- and Intra-Observer Variability in Conventional Pap Smears.

Johanna Pulkkinen1, Heini Huhtala2, Leena Anneli Krogerus3

  • 1Department of Pathology, Fimlab Laboratories, Tampere, Finland.

Acta Cytologica
|February 28, 2022
PubMed
Summary
This summary is machine-generated.

Reproducibility of cervical cytology diagnoses varies, with better consensus for high-grade lesions like endocervical adenocarcinoma (EAC) and adenocarcinoma in situ (AIS). Nuclear size and pleomorphism aid diagnosis, while degenerative changes hinder it.

Keywords:
Cervical cytologyEndocervical cellsInterobserverPap smearReproducibility

More Related Videos

Denver Papillae Protocol for Objective Analysis of Fungiform Papillae
10:50

Denver Papillae Protocol for Objective Analysis of Fungiform Papillae

Published on: June 8, 2015

14.5K
Collection, Isolation, and Flow Cytometric Analysis of Human Endocervical Samples
12:34

Collection, Isolation, and Flow Cytometric Analysis of Human Endocervical Samples

Published on: July 6, 2014

19.3K

Related Experiment Videos

Last Updated: Oct 2, 2025

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness
08:52

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Published on: March 18, 2022

3.1K
Denver Papillae Protocol for Objective Analysis of Fungiform Papillae
10:50

Denver Papillae Protocol for Objective Analysis of Fungiform Papillae

Published on: June 8, 2015

14.5K
Collection, Isolation, and Flow Cytometric Analysis of Human Endocervical Samples
12:34

Collection, Isolation, and Flow Cytometric Analysis of Human Endocervical Samples

Published on: July 6, 2014

19.3K

Area of Science:

  • Cytopathology
  • Cervical Pathology
  • Oncology

Background:

  • The Bethesda System for Reporting Cervical Cytology provides diagnostic criteria for cervical lesions.
  • Previous studies indicate variable reproducibility in diagnosing these lesions, with better consensus for high-grade changes.

Purpose of the Study:

  • To assess the inter- and intra-observer reproducibility of cervical cytology diagnoses.
  • To identify morphological features associated with diagnostic consensus in endocervical adenocarcinomas (EAC) and adenocarcinomas in situ (AIS).

Main Methods:

  • Four cytopathologists analyzed 167 Pap smears from patients with confirmed EAC, AIS, and high-grade intraepithelial lesions.
  • Reproducibility was assessed using kappa (κ) values for various diagnostic categories.
  • Morphological analysis was performed on smears with high and low observer consensus.

Main Results:

  • Overall inter-observer κ-values ranged from 0.082 (atypical) to 0.412 (preneoplastic/neoplastic).
  • Overall intra-observer κ-values ranged from 0.241 (atypical) to 0.616 (squamous vs. glandular).
  • Nuclear size >2x normal and pleomorphism correlated with good consensus for EAC/AIS; lack of nuclear enlargement and degenerative changes correlated with poor consensus.

Conclusions:

  • Reproducibility was better for preneoplasia/neoplasia diagnoses than for atypia and NILM (negative for intraepithelial lesion or malignancy).
  • Neoplasia-associated features, such as nuclear enlargement and pleomorphism, improved diagnostic agreement for EAC and AIS.