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Updated: Oct 2, 2025

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Artificial Learning and Machine Learning Applications in Spine Surgery: A Systematic Review.

Cesar D Lopez1, Venkat Boddapati1, Joseph M Lombardi1

  • 1Department of Orthopaedic Surgery, The Spine Hospital, 21611New York-Presbyterian/Columbia University Irving Medical Center, New York, NY, USA.

Global Spine Journal
|March 1, 2022
PubMed
Summary

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Artificial intelligence and machine learning (AI/ML) show promise in spine surgery for patient selection and predicting costs and length of stay. However, AI/ML models are less accurate for predicting postoperative complications and readmissions.

Area of Science:

  • Spine Surgery
  • Artificial Intelligence
  • Machine Learning
  • Health Informatics

Background:

  • Spine surgery is increasingly utilizing advanced computational tools.
  • Optimizing patient selection and predicting outcomes are critical challenges in spine surgery.
  • The application of AI/ML in spine surgery is rapidly expanding.

Purpose of the Study:

  • To systematically review and evaluate research on AI/ML applications in spine surgery.
  • To assess AI/ML's role in preoperative patient selection.
  • To analyze AI/ML's effectiveness in predicting and managing postoperative outcomes and complications.

Main Methods:

  • Comprehensive literature search of EMBASE, Medline, and PubMed databases.
Keywords:
artificial intelligencedeep learningmachine learningorthopedic surgerypredictive modelingspine surgery

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  • Inclusion of all research-based studies regardless of evidence level or publication date.
  • Reporting of findings according to PRISMA guidelines.
  • Main Results:

    • 41 studies were included in the review.
    • Bayesian networks achieved the highest average AUC (.80), while neural networks showed the best accuracy (83.0%).
    • AI/ML models excelled in preoperative planning, cost prediction, and length of stay prediction, but were less accurate for readmissions/reoperations.

    Conclusions:

    • AI/ML presents a valuable tool for optimizing spine surgery patient care and cost-efficiency.
    • AI/ML models demonstrate superior performance in preoperative optimization and length of stay prediction.
    • Further development is needed to improve AI/ML accuracy in predicting postoperative complications and readmissions in spine surgery.