Avenues for post-translational protein modification prevention and therapy
1Department of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, MA, 02114, USA.
Molecular Aspects of Medicine
|March 1, 2022
Summary
Targeting harmful non-enzymatic post-translational modifications (nPTMs) like protein carbamylation and advanced glycation end products (AGEs) shows promise for treating cardiovascular disease (CVD), chronic kidney disease (CKD), and diabetes complications.
Area of Science:
- Biochemistry
- Molecular Biology
- Pathophysiology
Background:
- Non-enzymatic post-translational modifications (nPTMs) are increasingly recognized as key contributors to disease development.
- Protein carbamylation and glycation, leading to advanced glycation end products (AGEs), are significant nPTMs implicated in various pathologies.
Purpose of the Study:
- To review and discuss therapeutic strategies targeting protein carbamylation and AGEs.
- To explore the clinical implications of mitigating these nPTMs in chronic kidney disease (CKD), cardiovascular disease (CVD), and diabetes.
Main Methods:
- Literature review of experimental and established therapeutic options for nPTMs.
- In-depth case studies focusing on carbamylation in kidney disease and AGEs in metabolic disorders.
Main Results:
- Protein carbamylation is linked to CVD and mortality in CKD patients.
- AGEs are associated with complications of diabetes.
- Therapeutic interventions to reduce nPTM burden are being investigated.
Conclusions:
- Reducing protein carbamylation and AGE burden presents a promising therapeutic avenue for managing CKD, CVD, and diabetes.
- Further research is needed to confirm the clinical efficacy of these anti-nPTM strategies in humans.
Keywords:
CarbamylationCardiovascular diseasesChronic kidney diseaseDiabetes mellitusGlycationPost-translational modificationMore Related Videos
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