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Subtypes of Alzheimer's disease: questions, controversy, and meaning
Jacob W Vogel1, Oskar Hansson2
1Penn/CHOP Lifespan Brain Institute, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.
Trends in Neurosciences
|March 1, 2022
Abstract:
The distribution of Alzheimer's disease (AD) tau pathology varies systematically and causes a diverse array of syndromes. This forum article provides a brief overview of key controversies in untangling the complexity of AD subtypes, explores potential causes of AD variability in the population, and discusses clinical relevance and future directions of research into AD heterogeneity.