Optic Disk Pit Maculopathy Treatment Using a Human Amniotic Membrane Patch: One-Year Results

Area of Science:

• Ophthalmology
• Regenerative Medicine

Background:

• Optic disc pit maculopathy (ODPM) is a rare congenital condition.
• It can lead to significant visual impairment due to associated subretinal and intraretinal fluid accumulation.

Purpose of the Study:

• To evaluate the 1-year efficacy of human amniotic membrane (HAM) patch implantation for ODPM.
• To assess fluid reabsorption, visual acuity changes, and complications following HAM patch implantation.

Main Methods:

• A prospective, interventional study involving 11 patients with ODPM.
• All patients underwent pars plana vitrectomy with HAM patch implantation into the optic disc pit.
• Endotamponade with air was used, and outcomes included fluid reabsorption and visual acuity.

Main Results:

• Mean central retinal thickness decreased from 512 µm to 243 µm at 12 months.
• Mean visual acuity improved from 20/80 to 20/32.
• Complete or partial fluid resorption was observed in all 11 eyes (100%), with no recurrence or complications reported.

Conclusions:

• Human amniotic membrane patch implantation is a potentially effective treatment for optic disc pit maculopathy.
• The procedure demonstrated anatomical improvement and encouraging visual recovery in the studied cohort.
• HAM patches remained detectable, suggesting sustained structural support within the optic disc pit.