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Related Experiment Video

Updated: Oct 2, 2025

Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report

Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report

Published on: February 12, 2018

Optic Disk Pit Maculopathy Treatment Using a Human Amniotic Membrane Patch: One-Year Results.

Tomaso Caporossi¹, Guglielmo D'Amico¹, Ruggero Tartaro²

¹From Department of Ophthalmology, Catholic University of Sacred-Heart Foundation "Policlinico Universitario A. Gemelli" IRCCS, Rome (T.C, G.D'A, A.S, G.A, U.DeV, S.R).

American Journal of Ophthalmology

|March 1, 2022

Summary

This summary is machine-generated.

Human amniotic membrane patch implantation effectively treated optic disc pit maculopathy, leading to significant fluid reduction and improved vision. This minimally invasive approach showed anatomical and visual recovery in most patients over one year.

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Published on: May 26, 2023

Area of Science:

Ophthalmology
Regenerative Medicine

Background:

Optic disc pit maculopathy (ODPM) is a rare congenital condition.
It can lead to significant visual impairment due to associated subretinal and intraretinal fluid accumulation.

Purpose of the Study:

To evaluate the 1-year efficacy of human amniotic membrane (HAM) patch implantation for ODPM.
To assess fluid reabsorption, visual acuity changes, and complications following HAM patch implantation.

Main Methods:

A prospective, interventional study involving 11 patients with ODPM.
All patients underwent pars plana vitrectomy with HAM patch implantation into the optic disc pit.
Endotamponade with air was used, and outcomes included fluid reabsorption and visual acuity.

Main Results:

Mean central retinal thickness decreased from 512 µm to 243 µm at 12 months.
Mean visual acuity improved from 20/80 to 20/32.
Complete or partial fluid resorption was observed in all 11 eyes (100%), with no recurrence or complications reported.

Conclusions:

Human amniotic membrane patch implantation is a potentially effective treatment for optic disc pit maculopathy.
The procedure demonstrated anatomical improvement and encouraging visual recovery in the studied cohort.
HAM patches remained detectable, suggesting sustained structural support within the optic disc pit.