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Updated: Oct 2, 2025

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection
Published on: July 21, 2013
A case of ischemic stroke accompanied by multiple arterial dissections associated with Klippel-Feil syndrome
Kazuhiko Sato1, Yukako Yazawa2, Shota Igasaki2
1Department of Neurology, Tohoku Medical and Pharmaceutical University Hospital, 1-15-1 Fukumuro, Miyagino-ku, Sendai, Miyagi, 983-8536, Japan; Department of Stroke Neurology, Kohnan Hospital, 4-20-1 Nagamachi-minami, Taihaku-ku, Sendai, Miyagi, 982-8523, Japan.
Objectives:
To describe the case of an ischemic stroke patient with Klippel-Feil syndrome who developed multiple aneurysms and discuss the mechanism of aneurysm development.
Materials And Methods:
A 44-year-old man presented with dizziness, left hemiparesis, and left-sided numbness and was admitted to our department. He developed multiple aneurysms at the bilateral vertebral artery (VA) and bilateral internal carotid artery.
Results:
We diagnosed the etiology of his brain infarction as an embolic stroke caused by left VA dissection or the large thrombosed aneurysm. Furthermore, we considered that arterial dissection or Hox gene mutation was associated with the development of multiple aneurysms.
Conclusion:
While previous reports have described single aneurysm, this is the first report of multiple aneurysms associated with Klippel-Feil syndrome.
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