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Generating Recombinant Avian Herpesvirus Vectors with CRISPR/Cas9 Gene Editing
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Therapeutic potentials of CRISPR-Cas genome editing technology in human viral infections

Sajad Najafi1, Shing Cheng Tan2, Shahin Aghamiri1

  • 1Student Research Committee, Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|March 1, 2022
PubMed

Insights

CRISPR-Cas9 gene editing shows promise for treating viral infections, including COVID-19. Research is advancing delivery methods and addressing challenges for clinical use.

Area of Science:

  • Molecular Biology
  • Gene Therapy
  • Virology

Background:

  • Viral infections cause significant global morbidity.
  • The COVID-19 pandemic heightened interest in novel antiviral therapeutics.
  • CRISPR-Cas9 technology is emerging as a potential tool for viral disease treatment.

Purpose of the Study:

  • To review the current research on CRISPR-Cas technology for treating viral infections.
  • To discuss strategies for enhancing in vivo delivery of CRISPR-Cas systems.
  • To identify challenges and future research directions for clinical application.

Main Methods:

  • Literature review of CRISPR-Cas applications in virology.
  • Analysis of gene-editing strategies for viral disease therapy.
  • Discussion of in vivo delivery systems and clinical challenges.

Main Results:

  • CRISPR-Cas technology demonstrates potential for targeting and eliminating viral genetic material.
  • Various delivery methods, including viral and non-viral vectors, are being explored.
  • Significant challenges remain in achieving efficient and safe in vivo delivery and clinical translation.

Conclusions:

  • CRISPR-Cas technology offers a promising avenue for developing novel antiviral therapies.
  • Further research is needed to optimize delivery systems and overcome safety concerns for widespread clinical use.
  • Addressing current limitations will pave the way for CRISPR-Cas-based treatments against viral diseases.
Keywords:
CRISPR-CasGene editingInfectionTreatmentVirus

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