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SuperSonic shear imaging for the differentiation between benign and malignant thyroid nodules: a meta-analysis
1Department of Endocrinology, The Second Affiliated Hospital of Fujian Medical University, No. 34 North Zhongshan Road, Quanzhou, 362000, Fujian, China.
Journal of Endocrinological Investigation
|March 1, 2022
Summary
SuperSonic shear imaging (SSI) accurately differentiates benign from malignant thyroid nodules. This noninvasive technique shows high diagnostic accuracy, making it a valuable tool for evaluating thyroid nodules.
Area of Science:
- Radiology
- Medical Imaging
- Diagnostic Accuracy
Background:
- Thyroid nodules are common, and differentiating benign from malignant ones is crucial for appropriate management.
- Accurate noninvasive diagnostic tools are needed to reduce unnecessary biopsies.
Purpose of the Study:
- To evaluate the diagnostic performance of SuperSonic shear imaging (SSI) in distinguishing between benign and malignant thyroid nodules using a meta-analysis approach.
Main Methods:
- A comprehensive literature search was conducted across major databases (PubMed, EMBASE, Cochrane Library, Web of Science) up to July 2021.
- The Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool assessed study quality.
- Meta-analysis calculated summary sensitivity, specificity, area under the receiver operating characteristic curve (AUROC), and diagnostic odds ratio (DOR).
Main Results:
- The meta-analysis included 21 studies with 3376 patients and 4296 thyroid nodules (42.0% malignancy rate).
- SuperSonic shear imaging demonstrated a summary sensitivity of 74% and specificity of 82%.
- The summary AUROC was 0.85, indicating high diagnostic accuracy for differentiating thyroid nodules.
Conclusions:
- SuperSonic shear imaging exhibits high accuracy in differentiating benign from malignant thyroid nodules.
- SSI serves as a valuable, noninvasive adjunct for thyroid nodule evaluation.
- This technique can aid in clinical decision-making for thyroid nodule management.
