Related Experiment Video
Updated: Oct 2, 2025

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae
Published on: February 25, 2022
TAR DNA-binding protein 43 oligomers in physiology and pathology
Yuh Shen Lye1,2, Yun-Ru Chen1,2
1Genomics Research Center, Academia Sinica, Taipei, Taiwan.
Abstract:
TAR DNA-binding protein 43 (TDP-43) is an RNA/DNA-binding protein involved in RNA regulation and diseases. In 2006, TDP-43 inclusions were found in the disease lesions of several neurodegenerative diseases. It is the pathological hallmark in both amyotrophic lateral sclerosis and frontotemporal lobar dementia. It also presents in a large portion of patients with Alzheimer's disease. TDP-43 is prone to aggregate; however, the role of TDP-43 oligomers remains poorly understood in both physiological and pathological conditions. In this review, we emphasize the role of oligomeric TDP-43 in both physiological and pathological conditions and discuss the potential mechanisms of oligomer formation. Finally, we suggest therapeutic strategies against the TDP-43 oligomers in neurodegenerative diseases.
Related Concept Videos
Single-Strand DNA Binding Proteins
Cooperative Binding of Transcription Regulators
Master Transcription Regulators
Covalently Linked Protein Regulators
These groups modify specific amino acids in a protein....
General Transcription Factors
Ligand Binding and Linkage

