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Updated: Oct 2, 2025
Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture
Published on: September 29, 2017
Ionic liquid functionalized injectable and conductive hyaluronic acid hydrogels for the efficient repair of diabetic
Pan Liu1, Kai Jin2, Yuange Zong1
1Key Laboratory of Catalysis and Energy Materials Chemistry of Ministry of Education & Hubei Key Laboratory of Catalysis and Materials Science & Key Laboratory of Analytical Chemistry of the State Ethnic Affairs Commission, South-Central University for Nationalities, Wuhan 430074, China. lichychem@mail.scuec.edu.cn.
Abstract:
The treatment and care of diabetic wounds remains a global challenge due to the high rates of amputation, recurrence, and mortality. It has been proven that electrical stimulation has a positive effect on promoting diabetic wound healing. Hyaluronic acid is an acidic mucopolysaccharide that exhibits important physiological functions in the body. However, it is not an ideal electrical substrate because of its poor electrical conductivity. In this work, a series of novel ionic liquid functionalized injectable and conductive hydrogels was prepared based on hyaluronic acid. The obtained hydrogels exhibited excellent electrical conductivity, flexibility and mechanical properties, and conferred significant antibacterial effects without the need for additional antibiotics. These hydrogels coupled with exogenous electrical stimulation can significantly accelerate diabetic wound healing compared with the commercial Tegaderm™ film.
