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Updated: Oct 2, 2025
Author Spotlight: A Unique Mouse Model of Asphyxia-Induced Cardiac Arrest
Published on: April 14, 2023
A comprehensive neuromonitoring approach in a large animal model of cardiac arrest
Filippo Annoni1, Lorenzo Peluso1, Lucas Akira Hirai2
1Intensive Care Experimental Laboratory, Intensive Care Unit, Erasme Hospital, Brussel, Belgium.
Background:
Anoxic brain injuries represent the main determinant of poor outcome after cardiac arrest (CA). Large animal models have been described to investigate new treatments during CA and post-resuscitation phase, but a detailed model that includes extensive neuromonitoring is lacking.
Method:
Before an electrically-induced 10-minute CA and resuscitation, 46 adult pigs underwent neurosurgery for placement of a multifunctional probe (intracranial pressure or ICP, tissue oxygen tension or PbtO2 and cerebral temperature) and a bolt-based technique for the placement and securing of a regional blood flow probe and two sEEG electrodes; two modified cerebral microdialysis (CMD) probes were also inserted in the frontal lobes and accidental misplacement was prevented using a perforated head support.
Result:
42 animals underwent the CA procedure and 41 achieved the return of spontaneous circulation (ROSC). In 4 cases (8.6%) an adverse event took place during preparation, but only in two cases (4.3%) this was related to the neurosurgery. In 6 animals (13.3%) the minor complications that occurred resolved after probe repositioning.
Conclusion:
Herein we provide a detailed comprehensive neuromonitoring approach in a large animal model of CA that might help future research.
