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Updated: Oct 2, 2025

05:31
A Fluorescent Screening Assay for Identifying Modulators of GIRK Channels
Published on: April 24, 2012
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Design and development of selective competitive fluorescent ligands for the detection and visualization of Kv7.2/7.3
Zhen Qiao1, Siyuan Tang1, Jialiang Guan2
1Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China. limingshao@fudan.edu.cn.
Abstract:
A series of specific and potent fluorescent ligands were developed for labelling and visualizing Kv7.2/7.3 based molecular rotation restriction. Probes 21b and 24a were found to be safe and convenient tools to detect and visualize Kv7.2/7.3 in live cells and mouse brain tissue.

