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Related Experiment Video

Updated: Oct 1, 2025

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
08:32

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

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Multi-Omics Profiling of the Tumor Microenvironment.

Oliver Van Oekelen1, Alessandro Laganà2

  • 1Department of Genomics and Data Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Advances in Experimental Medicine and Biology
|March 1, 2022
PubMed
Summary

Understanding the tumor microenvironment (TME) is crucial for cancer research. Multimodal single-cell omics technologies offer new ways to study TME complexity, improving cancer prognosis and treatment strategies.

Keywords:
BioinformaticsImmuno-oncologyImmunologyMulti-omicsNext-generation sequencingSystems biologyTumor microenvironment

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Area of Science:

  • Oncology
  • Immunology
  • Genomics

Background:

  • The tumor microenvironment (TME) comprises dynamic interactions between cancer cells and surrounding immune and stromal cells, contributing to patient heterogeneity.
  • The TME plays a critical role in cancer progression and influences the efficacy of immunotherapies like CAR T cells.
  • Understanding TME complexity is essential for improving cancer prognosis and developing targeted therapies.

Purpose of the Study:

  • To highlight the significance of the tumor microenvironment in cancer research.
  • To summarize multimodal single-cell omics technologies for TME characterization.
  • To discuss computational tools and clinical implications for TME-focused cancer studies.

Main Methods:

  • Utilizing multimodal omics technologies for single-cell resolution analysis of the TME.
  • Employing computational tools for data integration and analysis of TME components.
  • Investigating crosstalk between different cellular components within the TME.

Main Results:

  • Multimodal single-cell omics provide unprecedented insights into TME composition and heterogeneity.
  • Characterizing the TME aids in understanding treatment responses, particularly for immunotherapies.
  • Advanced computational methods enable detailed analysis of TME interactions.

Conclusions:

  • The TME is a central focus in modern cancer research, offering new therapeutic avenues.
  • Single-cell omics technologies are revolutionizing our ability to study the TME.
  • Further research into the TME holds significant promise for advancing cancer treatment strategies.