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Updated: Oct 1, 2025

Methods for the Study of Regeneration in Stentor
Published on: June 13, 2018
Heart regeneration: 20 years of progress and renewed optimism
Jessica C Garbern1, Richard T Lee2
1Department of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, 7 Divinity Ave, Cambridge, MA 02138, USA; Department of Cardiology, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115, USA.
Abstract:
Cardiovascular disease is a leading cause of death worldwide, and thus there remains great interest in regenerative approaches to treat heart failure. In the past 20 years, the field of heart regeneration has entered a renaissance period with remarkable progress in the understanding of endogenous heart regeneration, stem cell differentiation for exogenous cell therapy, and cell-delivery methods. In this review, we highlight how this new understanding can lead to viable strategies for human therapy. For the near term, drugs, electrical and mechanical devices, and heart transplantation will remain mainstays of cardiac therapies, but eventually regenerative therapies based on fundamental regenerative biology may offer more permanent solutions for patients with heart failure.
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