New-Onset Ocular Myasthenia after Multisystem Inflammatory Syndrome in Children

Area of Science:

• Neurology
• Immunology
• Pediatrics

Background:

• Neurologic complications are recognized in multisystem inflammatory syndrome in children (MIS-C).
• Autoimmune mechanisms are suspected in the pathogenesis of MIS-C-associated neurologic sequelae.

Observation:

• A 6-year-old girl presented with symptoms of myasthenia gravis.
• The onset of myasthenia gravis occurred 11 weeks after SARS-CoV-2 infection and 8 weeks after MIS-C diagnosis.

Findings:

• This case highlights a potential link between SARS-CoV-2 infection, MIS-C, and the subsequent development of myasthenia gravis in a pediatric patient.
• The temporal relationship suggests a possible autoimmune pathway triggered by the preceding infections.

Implications:

• Further research is warranted to elucidate the specific autoimmune mechanisms underlying neurologic complications post-MIS-C.
• This case underscores the importance of considering autoimmune neuromuscular disorders in children with a history of SARS-CoV-2 infection and MIS-C.