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Related Experiment Video

Updated: Oct 1, 2025

Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording
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Biomedical engineering of two-dimensional MXenes.

Hui Huang1, Caihong Dong2, Wei Feng1

  • 1School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, PR China; Materdicine Lab, School of Life Sciences, Shanghai University, Shanghai 200444, PR China.

Advanced Drug Delivery Reviews
|March 1, 2022
PubMed
Summary

Two-dimensional MXenes, a novel class of nanomaterials, offer unique properties for advanced biomedical applications. This review details their synthesis, properties, and potential in areas like biosensing, therapeutics, and tissue engineering.

Keywords:
Biological effectBiomedical applicationsMXeneSurface engineeringSynthetic methodology

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Two-dimensional (2D) transition metal carbides, carbonitrides, and nitrides, known as MXenes (Mn+1XnTx), have emerged as highly promising materials.
  • Their unique ultrathin structure and diverse properties (electronic, optical, magnetic, mechanical, biological) drive significant interest in various fields.
  • MXenes are being explored as advanced biomaterials for innovative biomedical applications and fundamental scientific discoveries.

Purpose of the Study:

  • To systematically review the state-of-the-art advances in MXene-based biomaterials.
  • To focus on synthetic methodologies, surface engineering, properties, and biological effects of MXenes.
  • To elucidate the property-activity-effect relationship at the nano-bio interface for biomedical applications.

Main Methods:

  • Comprehensive literature review of MXene synthesis and surface modification techniques.
  • Analysis of the intrinsic properties of MXenes relevant to biological interactions.
  • Detailed examination of MXene applications in biosensing, antibacteria, bioimaging, therapeutics, theranostics, and tissue engineering.

Main Results:

  • MXenes exhibit tunable properties through synthesis and surface engineering, enabling tailored biomaterial design.
  • Significant progress has been made in utilizing MXenes for biosensors, drug delivery, imaging, and regenerative medicine.
  • The nano-bio interface properties are crucial for understanding MXene activity and optimizing therapeutic outcomes.

Conclusions:

  • MXenes hold immense potential as versatile biomaterials across a wide spectrum of biomedical applications.
  • Addressing current challenges in synthesis, biocompatibility, and long-term effects is key for clinical translation.
  • Further research into the property-activity-effect relationship will accelerate the practical realization of MXene-based biomedical technologies.