Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Telomeres and Telomerase02:41

Telomeres and Telomerase

5.9K
5.9K
Aging01:26

Aging

232
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
232
Mitochondria01:37

Mitochondria

15.4K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
15.4K
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

2.7K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
2.7K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.8K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.8K
Replication in Eukaryotes01:29

Replication in Eukaryotes

15.0K
In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
15.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

Correction to: 'Pollination by hoverflies in the Anthropocene' (2020), by Doyle et al.

Proceedings. Biological sciences·2026
Same journal

From colour to heat: linking visible and near-infrared reflectance in birds.

Proceedings. Biological sciences·2026
Same journal

On the origins of aesthetic experience: interpreting evidence from infant studies.

Proceedings. Biological sciences·2026
Same journal

Hybridization with wild individuals fuels reindeer feralization.

Proceedings. Biological sciences·2026
Same journal

Emergence of functional prey depletion halo through penguin-krill behavioural dynamics.

Proceedings. Biological sciences·2026
Same journal

Transparency, the ultimate camouflage? Background dependency and influence of background lightness.

Proceedings. Biological sciences·2026

Related Experiment Video

Updated: Oct 1, 2025

Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

17.3K

Cellular senescence, rejuvenation and potential immortality.

A Rupert Sheldrake1

  • 1Schumacher College, Totnes, UK.

Proceedings. Biological Sciences
|March 2, 2022
PubMed
Summary

Cellular damage accumulates with age, but cells can be rejuvenated. This study proposes the cellular rejuvenation hypothesis, suggesting cells can achieve potential immortality by excreting damaged components via extracellular vesicles.

Keywords:
asymmetric cell divisioncancer cellscellular rejuvenationcellular senescencedamaged cell constituentsstem cells

More Related Videos

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
07:39

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

Published on: June 28, 2019

24.3K
Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

33.9K

Related Experiment Videos

Last Updated: Oct 1, 2025

Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

17.3K
SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
07:39

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

Published on: June 28, 2019

24.3K
Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

33.9K

Area of Science:

  • Cellular Biology
  • Gerontology
  • Molecular Biology

Background:

  • Two paradigms exist: universal senescence (inevitable aging) and potential immortality (some cells are immortal).
  • Cellular damage accumulation is observed, but dilution via growth and division occurs in some organisms.
  • Mammalian embryonic stem cells and cancer cells divide symmetrically yet replicate indefinitely, posing a question about their immortality.

Purpose of the Study:

  • To propose a unifying hypothesis for cellular senescence, rejuvenation, and potential immortality.
  • To explain how certain cell types, like mammalian stem cells and cancer cells, achieve indefinite replication.
  • To introduce the "cellular rejuvenation hypothesis" as a new synthesis of existing paradigms.

Main Methods:

  • Review of existing research on cellular senescence, damage accumulation, and cell division.
  • Analysis of mechanisms in unicellular organisms, germ cells, cancer cells, and mammalian stem cells.
  • Formulation of the "cellular rejuvenation hypothesis" based on observed phenomena.

Main Results:

  • Damaged cell constituents accumulate in all cells.
  • Growth and cell division, particularly asymmetric division, can dilute damaged components.
  • Extracellular vesicle-mediated excretion of damaged constituents is proposed as a rejuvenation mechanism for "immortal" cell lines.

Conclusions:

  • The cellular rejuvenation hypothesis integrates universal senescence and potential immortality.
  • Cells can be rejuvenated through growth and division or by excreting damaged components.
  • This hypothesis provides a framework for understanding and testing mechanisms of cellular immortality.