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Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells
Published on: July 6, 2021
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A feedback control principle common to several biological and engineered systems.
Jonathan Y Suen1, Saket Navlakha1
1Cold Spring Harbor Laboratory, Simons Center for Quantitative Biology, Cold Spring Harbor, NY, USA.
Journal of the Royal Society, Interface
|March 2, 2022
Summary
Discrete-event feedback control, using additive-increase and multiplicative-decrease rules, optimizes biological and engineered systems. These strategies enhance efficiency, resource allocation, and response times in distributed systems.
Area of Science:
- Control Theory
- Systems Biology
- Distributed Computing
Background:
- Traditional feedback control relies on continuous variable monitoring, which is resource-intensive.
- Discrete-event feedback offers a cost-effective alternative by using event-based signals.
- Optimizing discrete-event systems requires specialized strategies beyond traditional methods.
Purpose of the Study:
- To investigate parallels between discrete-event feedback control in biological and engineered systems.
- To identify common control rules employed across diverse biological and artificial systems.
- To understand how these rules support system goals like efficiency and adaptation.
Main Methods:
- Comparative analysis of feedback control strategies in biological and engineered systems.
- Identification of specific control rules: additive-increase and multiplicative-decrease.
- Case studies in harvester ant colonies, cell-size homeostasis, and neural circuits.
Main Results:
- Two engineering rules (additive-increase, multiplicative-decrease) are prevalent in biological systems.
- These rules are observed in ant foraging, cell-size regulation, and neural adaptation.
- The rules effectively optimize efficiency, resource sharing, and response latency.
Conclusions:
- Biological systems utilize discrete-event feedback control strategies analogous to engineering approaches.
- These shared strategies highlight universal principles of adaptation and optimization in distributed systems.
- Cross-disciplinary insights can advance both biological understanding and engineering algorithms.
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