Current status of herbal medicine research for respiratory diseases induced by particulate matter: a protocol for a
Jungtae Leem1, Yohwan Kim2, Kwan-Il Kim3
1Research Center of Traditional Korean Medicine, Wonkwang University, 460, Iksan-daero, Sin-dong, Iksan, Jeollabuk-do, 54538, Republic of Korea.
Background:
Particulate matter (PM) is an important environmental risk factor for the initiation and exacerbation of respiratory disease. Various herbal medicines have exhibited a reduction in symptoms of respiratory diseases induced by PM in animal models. However, the types and characteristics of studies on herbal medicine for respiratory diseases by PM have not been reviewed. This scoping review will focus on the currents status and research gap of herbal medicines for respiratory diseases caused by PM.
Methods:
We will follow the scoping review framework developed by Arksey and O'Malley. MEDLINE (via PubMed), EMBASE, and the Cochrane Central Register of Controlled Trials will be searched for relevant English-language publications, and only peer-reviewed, controlled comparative in vivo/in-vitro/human studies examining the effects of herbs on respiratory disease induced by PM will be included. The basic characteristics, research methods, detailed regimens, possible mechanisms, outcomes, and results will be extracted using a predefined standardized data extraction form. Outcomes will be presented in the following categories: pulmonary function, inflammatory markers, reactive oxygen species, histology and mechanisms, and adverse events. Two researchers will independently perform the study selection, data extraction, and quality assessment. We will also present the research map and implications for further study.
Ethics And Dissemination:
Ethical approval is not required because individual patient data will not be included. The findings will be disseminated through peer-reviewed publications or conference presentations.
Systematic Review Registration:
This review protocol has been registered with the Open Science Framework on February 12, 2021 ( https://osf.io/s7uvk/ ).
Insights
This scoping review examines herbal medicines for respiratory diseases caused by particulate matter (PM). It identifies current research and gaps, focusing on effects on pulmonary function and inflammation.
Area of Science:
- Environmental Health
- Pharmacology
- Respiratory Medicine
Background:
- Particulate matter (PM) is a significant environmental risk factor for respiratory diseases.
- Herbal medicines show promise in mitigating PM-induced respiratory symptoms in animal models.
- A comprehensive review of existing studies on herbal medicine for PM-related respiratory diseases is lacking.
Purpose of the Study:
- To conduct a scoping review on herbal medicines for respiratory diseases induced by particulate matter (PM).
- To identify the current status and research gaps in this field.
- To map the characteristics and findings of relevant studies.
Main Methods:
- Following the Arksey and O'Malley scoping review framework.
- Searched MEDLINE, EMBASE, and Cochrane Central Register for English-language, peer-reviewed, controlled comparative in vivo/in-vitro/human studies.
- Extracted data on study characteristics, regimens, mechanisms, outcomes (pulmonary function, inflammatory markers, ROS, histology, adverse events), and results.
Main Results:
- Data extraction and quality assessment performed by two independent researchers.
- Outcomes categorized into pulmonary function, inflammatory markers, reactive oxygen species, histology/mechanisms, and adverse events.
- A research map and implications for future studies will be presented.
Conclusions:
- This review will provide a comprehensive overview of the current research landscape.
- It aims to highlight areas for future investigation in herbal medicine for PM-induced respiratory diseases.
- Findings will inform the development of evidence-based herbal interventions.
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