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Author Spotlight: Expression and Purification of Human Solute Carrier Transporters Using Codon-Optimized Genes
Published on: September 29, 2023
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Targeting solute carriers to modulate receptor-ligand interactions
Hubert J Sijben1, Giulio Superti-Furga2, Adriaan P IJzerman1
1Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
Trends in Pharmacological Sciences
|March 2, 2022
Summary
Solute carrier transporters (SLCs) regulate receptor activity by controlling ligand movement. Emerging research highlights SLCs
Area of Science:
- Biochemistry and molecular biology
- Cellular signaling pathways
- Drug discovery and development
Background:
- Solute carrier transporters (SLCs) play a critical role in cellular physiology.
- SLCs are known to influence the availability of extracellular ligands.
- Recent evidence suggests SLCs modulate both intracellular and plasma membrane receptors.
Purpose of the Study:
- To review recent advancements in understanding SLC transporter functions.
- To explore the mechanisms by which SLCs modulate receptor activity.
- To discuss the therapeutic potential of targeting SLCs for various diseases.
Main Methods:
- Literature review of recent studies on SLCs and receptor modulation.
- Analysis of emerging concepts in ligand-receptor interactions mediated by SLCs.
- Evaluation of current and future therapeutic strategies involving SLCs.
Main Results:
- SLCs limit receptor activation through extracellular ligand uptake.
- SLCs modulate intracellular receptors via ligand influx.
- SLCs modulate plasma membrane receptors via ligand efflux.
Conclusions:
- SLC transporters are key regulators of receptor signaling.
- Targeting SLCs offers promising therapeutic avenues.
- Further research into SLC-mediated modulation is crucial for drug development.
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