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Updated: Oct 1, 2025

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
Published on: November 29, 2024
IL-34 and coronary heart disease complicated with diabetes mellitus
Huiqing Liu1, Fengbiao Jin2, Qinglian Li3
1Department of Cardiac Electrophysiology, Hospital Affiliated to Chengde Medical University, Chengde Hebei 067000. Liuhuiqingde@163.com.
Abstract:
Coronary heart disease and diabetes mellitus are closely related to chronic low-grade inflammation. Interleukin-34 (IL-34) is a new member of the interleukin family discovered in recent years. It is involved in the pathophysiological process of mononuclear phagocyte system mainly via binding to colony stimulating factor-1 receptor, and it is closely related to inflammatory and autoimmune diseases. IL-34 is highly expressed in patients with coronary heart disease or diabetes mellitus. IL-34 induces atherosclerosis and insulin resistance through multiple pro-inflammatory actions, ultimately leading to the occurrence and development of coronary heart disease, type 2 diabetes, and their comorbidities.
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