Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

256
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
256
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

231
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
231
Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

154
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
154
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents01:24

Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents

765
In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
765
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

220
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
220
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

243
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
243

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chemerin as a biomarker of inflammatory bowel diseases: a meta-analysis.

BMC gastroenterology·2025
Same author

Exploring the impact of acute viral exposure on clinical characteristics and antibody profiles in antiphospholipid syndrome: a study in CAPSTONE.

Clinical and experimental medicine·2024
Same author

Clinical features of 44 patients with small bowel Crohn<b>'</b>s disease.

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences·2021
Same author

A case of Crohn's disease combined with inflammatory myofibroblastoma of abdominal wall.

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences·2021
Same author

Changes in the intestinal microecology induced by bacillus subtilis inhibit the occurrence of ulcerative colitis and associated cancers: a study on the mechanisms.

American journal of cancer research·2019
Same author

[Small fugal enteritis manifestation with intestinal obstruction and hematochezia: a case report].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences·2017

Related Experiment Video

Updated: Oct 1, 2025

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
06:19

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis

Published on: May 16, 2025

376

Optimized treatment for severe ulcerative colitis: A case report.

Meichun Long1, Min Liu2, Chuancong Wu2

  • 1Department of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013. dmccllzz@163.com.

Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences
|March 2, 2022
PubMed
Summary
This summary is machine-generated.

Severe ulcerative colitis requires comprehensive treatment beyond conventional drugs. Enhanced nutritional support and individualized therapies can significantly improve patient outcomes, reducing disease severity.

Keywords:
ineffective treatmentoptimized treatmentulcerative colitis

More Related Videos

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
07:06

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Published on: December 8, 2014

27.3K
Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
05:41

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

3.0K

Related Experiment Videos

Last Updated: Oct 1, 2025

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
06:19

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis

Published on: May 16, 2025

376
Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
07:06

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Published on: December 8, 2014

27.3K
Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
05:41

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

3.0K

Area of Science:

  • Gastroenterology
  • Internal Medicine
  • Surgical Oncology

Background:

  • Severe ulcerative colitis presents significant challenges, often necessitating colectomy when medical management fails.
  • Conventional treatments may be insufficient for rapidly progressive cases, leading to life-threatening complications.
  • Surgical intervention for ulcerative colitis carries risks, particularly for young women, impacting quality of life and reproductive health.

Observation:

  • A young female patient with severe ulcerative colitis refractory to conventional therapy experienced complications including hypotension shock.
  • Surgical intervention was indicated but posed significant risks regarding future quality of life, sexual function, and fertility.
  • An individualized treatment approach was implemented, focusing on standardized medical protocols, enhanced nutritional support, and intestinal microecology regulation.

Findings:

  • The integrated treatment strategy, emphasizing nutritional support and microecology regulation, successfully transitioned the patient's severe ulcerative colitis to a mild state.
  • This case highlights the critical role of nutritional support as a complementary therapy alongside established drug treatments for ulcerative colitis.
  • Individualized, multidisciplinary care can avert the need for surgery and improve outcomes in severe ulcerative colitis cases.

Implications:

  • Nutritional support should be considered a cornerstone of ulcerative colitis management, on par with pharmacological interventions.
  • Optimizing intestinal microecology may offer a novel therapeutic avenue for inflammatory bowel diseases.
  • Personalized treatment plans are essential for managing severe ulcerative colitis, especially in patients where surgery presents substantial risks.