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Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19
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Elevated Liver Enzymes along with Comorbidity Is a High Risk Factor for COVID-19 Mortality: A South Indian Study on

Narayanasamy Krishnasamy1, Karthick Rajendran2, Parimita Barua1

  • 1Institute of Hepatobiliary Sciences, Madras Medical College and Rajiv Gandhi Government General Hospital, Chennai, Tamil Nadu, India.

Journal of Clinical and Translational Hepatology
|March 2, 2022
PubMed

Insights

Elevated liver enzymes in patients with coronavirus 2019 (COVID-19) combined with comorbidities significantly increases the risk of death. This finding highlights the importance of monitoring liver function in COVID-19 patients with underlying health conditions.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Liver enzyme abnormalities are observed in COVID-19 patients.
  • The predictive value of elevated liver enzymes for COVID-19 mortality remains unclear.
  • This study investigates liver enzymes as a predictor of COVID-19 outcomes.

Purpose of the Study:

  • To determine if elevated liver enzymes at admission predict COVID-19 mortality.
  • To assess the combined predictive risk of elevated liver enzymes and comorbidities for COVID-19 outcomes.
  • To identify key indicators for predicting severe COVID-19 disease progression.

Main Methods:

  • Retrospective study of 1,512 hospitalized COVID-19 patients (March-May 2020).
  • Assessment of demography, clinical variables, COVID-19 severity, and laboratory parameters.
  • Analysis of liver enzyme levels (AST/ALT) and comorbidities in relation to patient outcomes.

Main Results:

  • 450/1,512 (29.76%) patients had elevated liver enzymes; 713/1,512 (47.16%) had comorbidities.
  • Elevated liver enzymes and comorbidities were associated with older age, ICU admission, and severe COVID-19 symptoms.
  • Elevated liver enzymes with comorbidity increased the risk of death by 5.3-fold (OR: 5.314) compared to comorbidity alone (OR: 4.096).

Conclusions:

  • Elevated liver enzymes at presentation are a significant predictor of mortality in COVID-19 patients.
  • The combination of elevated liver enzymes and comorbidities independently increases the risk of death in COVID-19 by at least 5-fold.
  • Monitoring liver function is crucial for risk stratification in COVID-19 patients, especially those with comorbidities.
Abstract

Keywords:
Alanine aminotransferaseAspartate aminotransferaseCOVID-19ComorbidityLiver enzymeSARS-CoV-2

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