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Impact of comorbidities on mortality in hospitalized patients with COVID-19: An experience from Iran
Firooz Toofan1, Seyed Mojtaba Hosseini1, Khalil Alimohammadzadeh1,2
1Department of Health Services Management, North Tehran Branch, Islamic Azad University, Tehran, Iran.
Insights
Patients with pre-existing chronic conditions face a higher risk of death from COVID-19. Multimorbidity significantly increases in-hospital mortality risk for COVID-19 patients.
Area of Science:
- Epidemiology
- Infectious Diseases
- Public Health
Background:
- The COVID-19 pandemic's global impact necessitates understanding clinical characteristics and prognostic factors.
- Limited information exists on how pre-existing conditions influence COVID-19 outcomes.
Purpose of the Study:
- To investigate the impact of pre-existing chronic comorbid conditions and multimorbidity on mortality risk in COVID-19 patients.
Main Methods:
- Retrospective, cross-sectional, observational, single-center study.
- Analysis of 2597 hospitalized COVID-19 patients from February to September 2020.
- Multivariate logistic regression to assess independent effects of pre-existing conditions.
Main Results:
- 36.5% of patients had at least one pre-existing condition.
- Older age, male sex, diabetes, cardiovascular disease, hypertension, cancer, chronic kidney disease, liver disease, and COPD were associated with increased mortality.
- Increased number of comorbidities correlated with higher odds of mortality.
Conclusions:
- Pre-existing comorbidities significantly increase the risk of in-hospital mortality in COVID-19 patients.
- Identifying and managing comorbidities is crucial for improving COVID-19 patient outcomes.
Background:
COVID-19 pandemic has spread all over the world. However, information regarding clinical characteristics and prognostic factors is scarce. The aim of this study was to explore the impact of preexistent chronic comorbid conditions and multimorbidity on risk of mortality in patients with COVID-19.
Materials And Methods:
We designed a retrospective, cross-sectional, observational, single-center study. Data were analyzed from all consecutive patients diagnosed with COVID-19 who admitted in a pandemic hospital affiliated with Tabriz University of Medical Sciences, Tabriz, Iran, from February 20, 2020, to September 25, 2020. The independent effects of preexistent conditions were evaluated using multivariate logistic regression model.
Results:
A total of 2597 hospitalized patients with COVID-19 were included. At least one preexistent condition was observed in 36.5% of study population. Multivariate logistic regression analysis showed that older age, male sex, diabetes, cardiovascular disease, hypertension, cancer, chronic kidney diseases, liver diseases, and chronic obstructive pulmonary disease were associated with increased risk of mortality. In addition, the number of comorbidities was significantly associated with increased odds of mortality compared to no-comorbidity.
Conclusion:
The results of this study suggest that patients with comorbidities have an increased risk of in-hospital mortality following COVID-19 infection.