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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
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Stimuli-responsive cyclodextrin-based supramolecular assemblies as drug carriers
Ying Yuan1, Tianqi Nie2, Yifen Fang3
1School of Biomedical Engineering, Sun Yat-sen University, Shenzhen, 518107, P. R. China. wujun29@mail.sysu.edu.cn.
Journal of Materials Chemistry. B
|March 2, 2022
Summary
Stimuli-responsive supramolecular assemblies using cyclodextrins (CDs) enable controlled biomedical applications. This review details advances in CD host-guest chemistry integrated with various stimuli for drug delivery and beyond.
Area of Science:
- Supramolecular Chemistry
- Biomedical Engineering
- Materials Science
Background:
- Cyclodextrins (CDs) possess unique structures valuable for diverse biomedical applications.
- Integrating host-guest chemistry with stimuli-responsive functions allows for spatiotemporal control in these applications.
- Supramolecular assemblies offer advanced platforms for targeted therapeutic delivery and diagnostics.
Purpose of the Study:
- To review recent advancements in stimuli-responsive supramolecular assemblies based on cyclodextrin host-guest chemistry.
- To explore the mechanisms and design principles of these assemblies in response to various stimuli.
- To highlight their applications in drug delivery and discuss future clinical translation.
Main Methods:
- Literature review of recent research on cyclodextrin-based supramolecular assemblies.
- Analysis of endogenous stimuli (pH, redox, enzymes) and exogenous stimuli (light, temperature, magnetic field).
- Discussion of design strategies for stimuli-responsive systems and their biomedical applications.
Main Results:
- CD-based supramolecular assemblies demonstrate significant potential for controlled drug delivery.
- Integration with stimuli allows for precise spatiotemporal release of therapeutic agents.
- Diverse applications beyond drug delivery are emerging, leveraging CD host-guest interactions.
Conclusions:
- Stimuli-responsive cyclodextrin supramolecular assemblies are a promising area for advanced biomedical applications.
- Further research and development are needed to overcome limitations and facilitate clinical translation.
- These systems offer tunable properties for sophisticated therapeutic strategies.
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