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Updated: Oct 1, 2025

Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase
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Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase

Published on: October 15, 2018

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The role of KMT2 gene in human tumors

Zhi-Long Zhang1,2, Peng-Fei Yu3, Zhi-Qiang Ling4

  • 1Zhejiang Cancer Institute (Experimental Research Center), Zhejiang Cancer Hospital, Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, PR China.

Histology and Histopathology
|March 2, 2022
PubMed

Insights

Histone methylation, regulated by KMT2 (lysine methyltransferase) genes, is vital for gene expression. KMT2 gene mutations are linked to various cancers, impacting tumor development and prognosis.

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Cancer Genetics

Background:

  • Histone methylation is a key epigenetic mechanism regulating gene transcription.
  • Aberrant methylation-modifying enzymes, including the KMT2 (lysine methyltransferase) family, are implicated in genetic diseases and human cancers.
  • KMT2 proteins regulate essential cellular processes like proliferation, growth, development, and differentiation via gene expression control.

Purpose of the Study:

  • To investigate the clinical characteristics and molecular mechanisms of KMT2 gene mutations in human tumors.
  • To understand the correlation between KMT2 mutation status and tumor occurrence, development, and prognosis.
  • To provide insights for early tumor diagnosis, prognosis, and targeted therapy development.

Main Methods:

  • Literature review of studies on KMT2 gene mutations in various human cancers.
  • Analysis of clinical data and molecular mechanisms associated with KMT2 mutations.
  • Comparative analysis of mutation status across different tumor types.

Main Results:

  • KMT2 gene mutations are frequently observed in diverse human cancers.
  • KMT2 mutation status shows potential correlation with tumor initiation, progression, and patient outcomes.
  • Specific KMT2 mutations may influence cellular functions related to cancer development.

Conclusions:

  • KMT2 gene mutations are significant factors in human tumorigenesis.
  • Understanding KMT2 mutation patterns can aid in predicting tumor behavior and patient prognosis.
  • Further research into KMT2 mutations may facilitate the development of novel targeted cancer therapies.

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