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Updated: Oct 1, 2025
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An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
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Cancer epigenetics: promises and pitfalls for cancer therapy
Eleni Skourti1, Paraminder Dhillon1
1The FEBS Journal Editorial Office, Cambridge, UK.
The FEBS Journal
|March 2, 2022
Summary
Epigenetic regulators are key in cancer development and treatment response. This collection explores their diverse roles, from chromatin to metabolism, offering insights into targeted cancer therapies.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Epigenetic regulators significantly influence cancer initiation, progression, and therapeutic response.
- This Special Issue compiles reviews on diverse epigenetic modulators in cancer.
Discussion:
- Topics include transposable elements, chromatin architecture, and oncohistones.
- Altered epigenetics impact transcription and advanced cancer cell phenotypes.
- The interplay between cancer metabolism, epigenetics, and transcription is examined.
Key Insights:
- Epigenetic alterations are central to cancer biology.
- Oncohistones represent a critical area of cancer-associated epigenetic research.
- Cancer metabolism links epigenetic changes to transcriptional dysregulation.
Outlook:
- Epigenetics holds significant promise for developing targeted cancer therapeutics.
- Understanding these mechanisms can lead to novel treatment strategies.
- This collection provides an overview of recent advances in cancer epigenetics.
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