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Does urinary urgency drive urinary frequency in overactive bladder?

Eboo Versi1, Eric S Rovner2, Roger R Dmochowski3

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Summary
This summary is machine-generated.

Selective bladder denervation (SBD) reduced urgency in overactive bladder patients, but increased non-urgency voids. This suggests habit voiding significantly impacts urinary frequency, warranting further study in OAB interventions.

Keywords:
QoLnonurgency voidsradiofrequency ablationrefractory OABtrigoneurgencyvoiding frequency

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Area of Science:

  • Urology
  • Minimally Invasive Procedures

Background:

  • Refractory overactive bladder syndrome (rOAB) significantly impacts quality of life.
  • Current treatments for rOAB have varying efficacy and side effect profiles.

Purpose of the Study:

  • To evaluate the correlation between reduced urgency and changes in voiding frequency and symptom bother in patients with rOAB.
  • To assess the efficacy of selective bladder denervation (SBD) in managing rOAB symptoms.

Main Methods:

  • Prospective analysis of women with rOAB undergoing radiofrequency ablation (SBD).
  • Data collected included 3-day voiding diaries (urgency voids, nonurgency voids, urgency urinary incontinence episodes) and quality of life measures (OAB-q SF).

Main Results:

  • Selective bladder denervation (SBD) significantly reduced urgency urinary incontinence and urgency voids (P < .001).
  • Nonurgency voids increased significantly (P < .001) post-treatment, while quality of life measures improved (P < .001).
  • Symptom bother correlated with urgency voids but inversely with nonurgency voids.

Conclusions:

  • Selective bladder denervation (SBD) effectively reduces overactive bladder (OAB) symptoms and improves quality of life.
  • The increase in nonurgency voids suggests habit or defensive voiding plays a key role in urinary frequency.
  • Further research into OAB interventions is needed to understand symptom genesis.