Related Experiment Video

Updated: Oct 1, 2025

An In Vitro Enzymatic Assay to Measure Transcription Inhibition by GalliumIII and H3 5,10,15-trispentafluorophenylcorroles
09:00

An In Vitro Enzymatic Assay to Measure Transcription Inhibition by GalliumIII and H3 5,10,15-trispentafluorophenylcorroles

Published on: March 18, 2015

11.7K

Corilagin exhibits differential anticancer effects through the modulation of STAT3/5 and MAPKs in human gastric

Min Hee Yang1,2, Seung Ho Baek3, Sun Tae Hwang2

  • 1KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul, Republic of Korea.

Phytotherapy Research : PTR
|March 2, 2022
PubMed

Insights

Corilagin (CLG), a natural tannin, shows anti-tumor effects by differentially regulating signaling pathways in gastric cancer cells. It induces apoptosis and enhances docetaxel efficacy, highlighting its potential as a cancer therapeutic.

Area of Science:

  • Pharmacology
  • Molecular Biology
  • Cancer Research

Background:

  • Corilagin (CLG) is a hydrolyzable tannin with known pharmacological activities.
  • Gastric cancer remains a significant global health challenge, necessitating novel therapeutic strategies.

Purpose of the Study:

  • To investigate the anti-tumor potential of Corilagin (CLG) against human gastric cancer cells.
  • To elucidate the underlying molecular mechanisms of CLG's anti-cancer effects, focusing on specific signaling pathways.

Main Methods:

  • Treatment of human gastric cancer cell lines (SNU-1 and SNU-16) with CLG.
  • Analysis of JAKs-Src-STAT3/5 and MAPK signaling pathways.
  • Assessment of apoptosis induction (sub-G1 phase accumulation, caspase-3 activation).
  • Combination treatment with CLG and docetaxel, followed by pathway inhibition studies.

Main Results:

  • CLG differentially regulated JAKs-Src-STAT3/5 and MAPK pathways in SNU-1 versus SNU-16 cells.
  • CLG induced apoptosis in both cell lines and enhanced the effects of docetaxel in SNU-1 cells.
  • MAPK pathway activation was crucial for CLG's anti-cancer effects, as evidenced by inhibition studies.

Conclusions:

  • CLG exhibits anti-tumor activity through distinct mechanisms in different gastric cancer cell lines.
  • CLG effectively blocks STAT3/5 activation in SNU-1 cells and induces sustained MAPK activation in SNU-16 cells.
  • CLG holds promise as a potential therapeutic agent for gastric cancer, particularly in combination therapy.
Keywords:
CorilaginSTAT3/5apoptosisgastric cancermitogen-activated protein kinases

More Related Videos

Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula09:03

Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula

Published on: January 26, 2024

486
Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment11:13

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Published on: June 9, 2023

1.8K

Related Concept Videos

mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.9K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.7K
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
5.0K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.6K
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.2K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.0K